摘要
分析中药沙苑子对运动性疲劳模型大鼠血清支链氨基酸（branched-chain amino acid,BCAA）及芳香族氨基酸（aromatic amino acid,AAA）的影响,为沙苑子作为运动保健品的开发利用提供实验依据.选用SD（Sprague Dawley,SD）雄性大鼠24只,体重190-230 g,随机分为安静对照组、一般训练组、强化训练组、强化加药组（各6只）,进行7周递增负荷跑台运动建立运动性疲劳大鼠模型,于第8周始运动即刻后取材,运用氨基酸自动分析仪测定大鼠血清游离氨基酸含量.结果表明,长时间耐力跑台运动应激使大鼠血清BCAA含量有所下降,AAA尤其是游离色氨酸（free-tryptophan,f-Trp）含量上升,沙苑子可抑制BCAA下降、AAA上升趋势;长时间耐力跑台运动使实验大鼠血清f-Trp/BCAA、AAA/BCAA显著增加,运动过程中血中蛋白质代谢增强,BCAA大量分解供能,AAA相对增多,从而使f-Trp/BCAA、AAA/BCAA增高.沙苑子可以抑制f-Trp/BCAA、AAA/BCAA上升,且对强化训练引起的f-Trp/BCAA、AAA/BCAA升高有显著的降低作用.沙苑子可促进强化训练大鼠AAA的消除,利于脑中AAA与BCAA间的平衡,改善机体对运动疲劳的适应能力,有利于推迟疲劳的发生.
Based on the effects of the semen astragali complanati on BCAA and AAA levels of blood in exercise-induced fatigue rats.24 male SD rats with weight 190-230 g were randomly divided into 4 groups as Sedentary Group,Model Group,Drill Group and Treatment Group.and given 7 weeks of endurance treadmill training and the free amino acids in serum were tested by amino acid automatic analytical instrument.The results showed that the content of serum branched chain amino acid（BCAA） and aromatic amino acid（AAA） especially free-tryptophan（f-Trp） were increased after a long treadmill exercise.The Semen astragali complanati could enhance the concentration of serum BCAA and lessen the concentration of serum AAA compared with that of the drill group.The ratios of f-Trp/BCAA and AAA/BCAA in serum were increased significantly after long duration of treadmill exercise,this is because the metabolim of blood protein was quickened during exercise and the BCAA dispelled to supply energy and the AAA increased.The Semen as tragali complanati could restrain the increase,The conclusion：Semen astragali complanati could benefit the balance of BCAA and AAA in brain then suspend exercise fatigue.
出处
《陕西师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2010年第2期104-108,共5页
Journal of Shaanxi Normal University：Natural Science Edition
基金
陕西省自然科学基金资助项目(2002C131)
关键词
沙苑子
运动性疲劳
支链氨基酸
芳香族氨基酸
semen astragali complanati exercise-induced fatigue branched chain amino acid aromatic amino acid
