摘要
背景:创伤愈合过程中,各种上皮细胞与表皮干细胞的相互交织作用在促进伤口愈合的机制中是十分复杂的,任何细微环节的异常都将会导致伤口延迟愈合或瘢痕形成。目的:总结上皮细胞与表皮干细胞的特征以及在创伤愈合中的相互交织作用,从形态学和分子生物学上提高对瘢痕形成机制的认识。方法:应用计算机检索PubMed数据库1974/2009期间上皮细胞与表皮干细胞在创伤愈合中的作用以及导致瘢痕形成的相关英文文章,检索词为"epithelial cells,epithelial stem cells,wound healing,keratinocytes,fibroblasts,hypertrophic scar,keloid";同时用计算机检索中国期刊全文数据库1999/2009期间的相关中文文章,检索词为"上皮细胞,表皮干细胞,创伤愈合,角质形成细胞,成纤维细胞,增生性瘢痕,瘢痕疙瘩"。经过筛选共收集到43篇文献。与细胞结构相关文章3篇,上皮细胞在创伤愈合与瘢痕形成中相关作用的文章16篇,表皮干细胞相关文章24篇。结果与结论:①上皮组织中各类上皮细胞的生理作用是明确已知的,其中研究最多的是角质形成细胞和成纤维细胞,并且与瘢痕形成密切相关。②目前已证实表皮干细胞的存在,但有关其定位、定性及具有特征性的表面标记物仍是值得进一步研究和探索的问题。③相信随着科学技术的发展,可以通过基因角度对表皮干细胞的进行调控,从而衍生出所需要的细胞以修复重建皮肤在创伤后的缺损,并防止瘢痕形成达到组织正常完美的愈合。
BACKGROUND：At the process of wound healing,the epithelial cells and epidermal stem cells interactions is complicated which promoting the mechanisms of wound healing.The abnormities of any fine phase can be result in delayed healing or scarring.OBJECTIVE：To summarize the characterization of epithelial cells and epidermal stem cells and their interaction in wound healing so that we can recognize the mechanisms of scarring from histomorphology,biochemistry and molecular variations.METHODS：A computer-based online search of Pubmed Database was undertaken to identify the relevant articles on epithelial cell and epidermal stem cells interactions in wound healing and results in scarring published from 1974 to 2009 with the Keywords of ＂epithelial cells,epithelial stem cells,wound healing,keratinocytes,fibroblasts,hypertrophic scar,keloid＂ in English.At the same time,Chinese relevant articles were searched in China Journal Full-text Database （CJFD） published between 1999 and 2009 with the same key words in Chinese.A total of 43 articles were collected about the cell structure （3 articles）,the cell interactions in wound healing and scarring （16 articles）,the relevant on epithelial stem cells （24 articles）.RESULTS AND CONCLUSION：The effect of different cells in epithelial tissue is known to all.The keratinocytes and fibroblasts had been on studying frequently,and their closely correlated to scarring.At present,the epithelial stem cells has been confirmed,but the relevant on their location,quality and specific epidermal markers are unclear which need to study and explore.With the rapidly development of science and technology,we maybe control the expression of cells by genic regulation not only culture the cells of our need but to prevent the scarring.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第6期1092-1096,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
云南省自然科学基金资助项目(2005C0072M)
云南省社会发展攻关项目(2007CA006)~~
