摘要
目的探讨多塞平在肺癌患者化学治疗(化疗)中的临床应用。方法将100例入组患者分成治疗组和对照组。治疗组60例,常规化疗加口服多塞平,配合心理支持治疗;对照组40例,常规化疗配合心理支持治疗。在治疗前和2,4,6周期化疗后,患者分别填写焦虑自评量表(SAS)及抑郁自评量表(SDS),根据量表评分的变化评价两组治疗效果和主要不良反应。结果治疗组2,4,6周期化疗后的总有效率分别为90.0%,85.0%,80.0%;对照组分别为65.0%,40.0%,36.0%。治疗组与对照组比较,2,4,6周期化疗后的总有效率差异均有极显著性(均P<0.01)。治疗组2,4,6周期间化疗后总有效率差异无显著性(P>0.05)。对照组2,4周期化疗后总有效率比较,差异有显著性(P<0.05),2,6周期化疗后比较,差异有极显著性(P<0.01),但4,6周期化疗后总有效率差异无显著性(P>0.05)。结论在肺癌患者化疗过程中应用多塞平配合心理支持治疗,可取得较好疗效,值得临床进一步研究。
Objective To investigate the clinical uses of doxepin on chemotherapy for patients with lung cancer.Methods 100 patients with lung cancer were enrolled into the study and all the patients were divided into two groups：therapeutic group and control group.60 patients in the therapeutic group were given with chemotherapy,doxepin and routine psychological support;40 other patients in the control group were given with chemotherapy and psychological support.The patients in both groups accepted questionnaires of self-rating anxiety scale（SAS）and self-rating depression scale（SDS）prior to treatment,2 cycles,4 cycles,6 cycles after chemotherapy.Then we evaluated the clinical effects and side effects according to the changes of standard scales.Results The total effective rates after 2,4,6 cycles of chemotherapy were 90.0%,85.0% and 80.0%,respectively.While in the control,the total effective rates were 65.0%,40.0% and 36.0%,respectively.Compared with the control group,the total effective rates were significantly different（P〈0.01）,while not inner groups（P〈0.05）.In the control group,the total effective rate of 2,4 cycles chemotherapy（P0.05）and 2,6 cycles of chemotherapy（P〈0.01）were obviously different.But the total effective rates of 4 and 6 cycles of chemotherapy were not mardedly different（P〉0.05）.Conclusion During the course of chemotherapy for lung cancer,doxepin plus psychological support is an effective method and deserved for further study.
出处
《医药导报》
CAS
2010年第4期467-468,共2页
Herald of Medicine
关键词
多塞平
肺癌
化学治疗
生活质量
Doxepin
Lung cancer
Chemotherapy
Quality of life
