摘要
咪唑并吡啶类化合物具有与吲哚、氮杂吲哚等类似的特殊结构和良好的生物活性,在医药和农药工业有着广泛的应用,成为有机化学家和药物化学家的研究热点。咪唑并吡啶类化合物主要有咪唑并[4,5-b]吡啶、咪唑并[4,5-c]吡啶、咪唑并[1,2-a]吡啶和咪唑并[1,5-a]吡啶等4个类型。本文阐述了近年来咪唑并吡啶类化合物的合成研究进展和应用情况,主要介绍了咪唑并[4,5-b]吡啶和咪唑并[4,5-c]吡啶这两类化合物的合成方法和在医药及农药领域的应用。
Imidazopyridine derivatives are of great importance for their remarkable biological properties.Their structrues are similar to those of indoles and azaindoles,two important heterocycles involved in many alkaloids.Many of them have been demonstrated as inhibitors of the target enzymes and used as medicines,herbicides and fungicides.The imidazopyridines comprise four important isomers：imidazo[4,5-b]pyridine,imidazo[4,5-c] pyridine,imidazo[1,2-a]pyridine,imidazo[1,5-a]pyridine.This paper reviews the advances in synthesis and application on imidazopyridines such as imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine derivatives in recent years.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2010年第4期631-638,共8页
Progress in Chemistry
基金
中国博士后科学基金项目(No.20080431024)
中南大学博士后科学基金
湖南省科技计划博士后专项(No.2009RS3029)资助
关键词
咪唑并吡啶
杂环化合物
合成
imidazopyridine derivatives
heterocycles
synthesis
