摘要
目的:研究反应性关节炎(ReA)患者外周血淋巴细胞亚群以及血清免疫球蛋白的变化及临床意义。方法:采用流式细胞术检测56例ReA患者和53例健康对照组外周血CD3+T、CD4+T、CD8+T、CD16+56+NK、CD19+B细胞的百分率;免疫比浊法检测血清IgG、IgA及IgM含量。结果:ReA患者与正常对照组比较,CD4+T淋巴细胞百分率、CD4+/CD8+比值及CD19+B淋巴细胞百分率均明显增高(P<0.01);血清IgG水平升高(P<0.05);CD15+56+NK细胞百分率明显降低(P<0.01);CD3+T、CD8+T淋巴细胞的百分率及血清IgM、IgA含量与正常对照组相比差异无统计学意义。结论:反应性关节炎患者体内细胞和体液免疫功能紊乱,监测ReA患者体内淋巴细胞亚群和免疫球蛋白水平,对于ReA的免疫治疗具有重要的临床意义。
Objective：To study the changes of lymphocyte subsets in peripheral blood and serum immunoglobulin of patients with reactive arthritis （ReA） and their clinical significance.Methods：CD3＋T,CD4＋T,CD8＋T,CD16＋56＋NK,CD19＋B positive rate （with flow cytometry） and serum IgG,IgA,IgM levels （with immuno-turbidity） were measured in 56 patients with ReA and 53 normal controls.Results：Compared with the normal controls,the percentage of CD4＋T lymphocyte,CD4＋/CD8＋ratio and CD19＋B cell percentage increased significantly （P0.01） in ReA patients.IgG level slightly increased （P0.05）.While,NK cell percentage reduced obviously （P0.01）.There were no statistical difference between ReA patients and normal controls about the levels of CD3＋T,CD8＋T cell and IgM,IgA （P0.05）.Conclusion：Cellular and humoral immune function were significantly abnormal in patients with reactive arthritis.Detection of lymphocyte subsets and serum immunoglobulin had important clinical significane for ReA＇s immunotherapy.
出处
《江苏大学学报（医学版）》
CAS
2010年第2期162-165,共4页
Journal of Jiangsu University：Medicine Edition
