摘要
目的:探讨胃腺癌EGFR基因表达及其与临床病理参数和术后5年生存率的关系。方法:显色原位杂交(CISH)检测55例胃腺癌组织EGFR基因表达。结果:55例胃腺癌组织EGFR基因扩增7例(阳性率12.7%);EGFR基因扩增患者5年生存率为14.3%,明显低于EGFR基因正常患者5年生存率(31.3%),χ2=11.935,P=0.001;阳性病例组织学类型均为肠型(Lauren分型);低分化(χ2=4.814,P=0.041)、浸及浆膜外(χ2=4.816,P=0.028)、临床分期为Ⅲ+Ⅳ期(χ2=4.786,P=0.029)以及有淋巴结转移(χ2=4.38,P=0.042)的胃腺癌EGFR基因扩增率明显增高。结论:EGFR基因扩增的胃腺癌分化程度低、易发生浆膜外浸润和淋巴结转移,临床分期为Ⅲ+Ⅳ期,术后5年生存率低。
OBJECTIVE：To investigate the expression of EGFR in gastric adenocarcinoma tissues,its clinical-pathological parameter and 5-year survival rate after operation.METHODS：The expression of EGFR gene in gastric adenocarcinoma（n=55）was detected by chromogenic in situ hybridization（CISH）.RESULTS：The amplification of EGFR gene was 12.7%,namely 7 cases of gastric adenocarcinoma.EGFR amplification was merely present in the intestinal type of gastric adenocarcinomas（according to Lauren＇s classification）.The 5-year survial rate of gastric adenocarcinoma whose EGFR gene amplified was 14.3%,significantly lower than that of cases whose EGFR gene not amplified（31.3%,χ2=11.935,P=0.001）.EGFR gene amplification in poorly-differentiated gastric adenocarcinoma,stage Ⅲ＋Ⅳ,extraserosa infiltration,lymphatic metastasis was significantly higher than that in well and moderately-differentiated gastric adenocarcinoma（χ2=4.814,P=0.041）,stageⅠ＋Ⅱ（χ2=4.786,P=0.029）,intraserosa infiltration（χ2=4.816,P=0.028）,no lymphatic metastasis（χ2=4.38,P=0.042）respectively.CONCLUSION：EGFR gene amplification is associated with the poor cell-differentiation,extraserosa infiltration,stage Ⅲ＋Ⅳ,lymphatic metastasis of gastric adenocarcinoma and a poor 5-year survival rate.
出处
《中华肿瘤防治杂志》
CAS
2010年第4期273-274,298,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
浙江省义乌市科研计划项目(08-3-07)
关键词
胃肿瘤/病理学
腺癌/病理学
基因
EGFR
原位杂交
stomach neoplasms/pathology
adenocarcinoma/pathology
genes
EGFR
in situ hybridization
