摘要
目的探讨促性腺激素释放激素激动剂（GnRH－a）在多翼卵巢综合征（PCOS）诱导排卵中的作用。方法对8例用克罗米芬无反应的PCOS患者，采用国产GnRH－a长期脱敏方案，达到垂体抑制后联合用国产HMG－HCG促排卵，共治疗17个周期。结果14个周期排卵（排卵率为82．4％），6例妊娠（周期妊娠率35．3％，累计妊娠率75．0％），5例足月活产（4例单胎，1例双胎），1例流产。1个周期出现重度卵巢过度刺激综合征（OHSS），2个周期出现中度OHSS，均为妊娠周期。结论对PCOS患者采用GnRH－a长期脱敏联合HMG可获得较高妊娠率，提高活产率，降低流产率，并减少严重OHSS的发生。
Objective To explore the effect of gonadotrophin-releasing hormoneagonist(GnRHa ) upon the ovulation induction of polycystic ovary syndrome(PCOS). Methods Eight cases of PCOSunresponsive to clomiphene were treated with long--term desensitization therapy of GnRH-a. Whenpituitary was controlled, HMG--HCG was used to to ovulation induction. Eight patients were treated for 17cycles. Results The ovulation rate was 82. 4 % (14 out of 17 cycles). Six patients were pregnant(pregnancy rate was 35. 3 %, per cycle,the total pregnancy rate was 75. 0% ), Among the six, one aborted,five gave term birth (including one twin). Severe ovarian hyperstimulation syndrome (OHSS) developedIn one cycle moderate OHSS in two cycles,all being pregnant cycles. Conclusion The result suggeststhat the co--treatment with long--trem therapy of GnRH--a and HMG for PCOS patients may increase thepatients' pregnancy rate, reduce the miscarriage rate and decrease severe OHSS.
出处
《中国全科医学》
CAS
CSCD
1998年第3期149-151,共3页
Chinese General Practice
关键词
多囊卵巢综合征
GNRH-A
诱导排卵
治疗
克罗米芬
Polycystic ovary syndrome Gonadotropin-releasing hormone agonist Ovulation induction
