摘要
目的分析捐献血小板人群的献血间隔和频采后的血小板功能状态,确保血小板的采集质量和献血者的自身健康。方法分别检测固定频采血小板捐献者(2次/月)和正常固定献血者(1次/月)的红细胞计数(RBC)、血红蛋白(Hb)、白细胞计数(WBC)、平均红细胞体积(MCV)、平均血红蛋白含量(MCH)、平均血红蛋白浓度(MCHC)、红细胞宽度标准差(RDW-SD)、血小板计数(Plt)、平均血小板体积(MPV)、血小板分布宽度(PDW)、体外血小板聚集率等指标并进行比较。结果RBC、Hb、WBC、MCV、MCHC、RDW-SD两组之间比较无显著性差异,Plt[(339.36±30.24)×109/Lvs.(248.25±20.61)×109/L,P<0.0001]、MPV[(8.44±0.52)flvs.(8.65±0.32)fl,P<0.001]、PDW[(15.52±1.13)%vs.(13.96±0.45)%,P<0.0001]及血小板体外聚集功能有显著性差异。结论频采者虽然有较高的Plt计数,但血小板的功能低于正常间隔血小板捐献者。因此,为保障血小板采集质量,应尽可能避免频繁采集血小板。
Objective To compare platelet function between regular multi platelet donation donors （2 times/month） and regular normal donors （1 time/month）, and assess specific parameters to make a rational analysis of the donation interval to ensure the quality of platelets used for clinical purposes. Methods RBC, HGB, MCV, MCHC, RDW-SD, PLT, MPV, PDW and platelet aggregation rate were used to compare donations from regular multi platelet donors and regular normal donors. Results The indices of RBC, WBC, HGH, MCV, average red cells and RDW-SD showed no significant differences between the two regular donor groups. Significant differences between the two donor groups were detected in PLT, MPV, PDW indices and the platelet aggregation assay. Conclusions Despite the relatively high platelet counts among regular multi platelet donations donors, their platelet’s ability to aggregate in vitro decrease compared with that of regular normal donors. It is recommended to collect platelet from regular normal donors to ensure the quality of the blood platelet donations
出处
《北京医学》
CAS
2010年第4期321-322,325,共3页
Beijing Medical Journal
关键词
成分献血者
血小板功能
血液质量
Platelet donors Platelet function Quality of platelets
