摘要
间充质干细胞(mesenchymal stem cells,MSCs)是一种具多向分化潜能的成体干细胞,具备修复心肌组织的能力。国内外学者做出了大量的努力,希望能够将干细胞移植治疗心脏疾病用于临床。但干细胞在移植后可发生大量的死亡,对治疗效果产生了重大影响。低氧是影响干细胞存活力较为重要的因素。低氧能够通过线粒体途径诱导MSC凋亡,使MSC的长期存活力下降。而抗凋亡途径(如磷脂酰肌醇3-激酶/AKT信号通路、核因子-κB途径)和抗凋亡蛋白(如Bcl-2相关蛋白、热休克蛋白、低氧诱导蛋白-1等)能够对抗低氧引起的细胞凋亡。利用这一原理,国内外学者采用了基因工程、预适应、药物联合治疗等策略以提高MSCs的长期存活率。
Mesenchymal stem cells（MSCs）,which are a type of adult stem cells with multiplex differentiation potential,have the ability to repair myocardium tissue.Great efforts had been made by the scholars to use stem cell transplantation for clinical treatment of cardiac disease.But after transplantation,large amounts of the stem cells are dead,which exerts negative effect on the therapy.Hypoxia is an important factor that affects the survival of stem cells.Through mitochondrial pathway,hypoxia can induce MSCs apoptosis to decrease its long term survival rate.Antiapoptotic pathways（like PI3k-Akt and NF-κB pathways） and antiapoptotic proteins（like bcl-2 super family,heat shock protein and hypoxia-inducible factor-1） are able to counteract hypoxia-induced apoptosis.Based on these reports,experts from domestic and abroad have developed strategies such as genetic engineering,preconditioning and combination therapy to improve the long term survival of MSCs.
出处
《国际病理科学与临床杂志》
CAS
2010年第1期76-80,共5页
Journal of International Pathology and Clinical Medicine
关键词
间充质干细胞
心肌修复
凋亡
低氧
基因工程
预适应
mesenchymal stem cells
myocardial repair
apoptotic
hypoxia
gene engineering
preconditioning
