胰腺癌分子靶向治疗的研究进展
Research Progress of Molecular Targeted Therapy for Pancreatic Cancer
摘要
随着对胰腺癌细胞分子生物学特性的深入了解,靶向治疗被认为是很有前景的治疗方法。至今,虽然其在临床前及早期临床试验中显示出较好的抗肿瘤活性,但多数靶向药物治疗胰腺癌的Ⅲ期临床试验结果并不理想。胰腺癌细胞的分子异质性可能是导致药物治疗失败的原因。
出处
《肿瘤学杂志》
CAS
2010年第3期233-237,共5页
Journal of Chinese Oncology
参考文献42
-
1Maitra A, Hruban RH. Pancreatic Cancer [J]. Annu Rev Pathol, 2008, 3:157-188.
-
2Rivera F, Lopez-Tarruella S, Vega-Villegas ME, et al. Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy[J]. Cancer Treat Rev, 2009, 35(4):335-339.
-
3Tobita K, Kijima H, Dowaki S, et al. Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis [J]. Int J Mol Med, 2003, 11(3):305-309.
-
4Gazdar AE, Shigematsu H, Herz J, et al. Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? [J]. Trends Mol Med, 2004, 10(10):481-486.
-
5Ellis LM. Epidermal growth factor receptor in tumor anglogenesis [J]. Hematol Oncol Clin North Am, 2004, 18(5): 1007-10021.
-
6Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins [J]. Nat Rev Mol Cell Biol, 2005, 6(8):635-645.
-
7Ahomare DA, Tanno S, DE Rienzo A, et al. Frequent activation of AKT2 kinase in human pancreatic carcinomas [J]. J Cell Biochem, 2002, 87(4):470-476.
-
8Trevino JG, Summy JM, Gray M J, et al. Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis [J]. Cancer Res, 2005, 65(16):7214-7222.
-
9Mahalingam D, Giles F. Challenges in developing targeted therapy for pancreatic adenocarcinoma [J]. Expert Opin Ther Targets, 2008, 12(11):1389-1401.
-
10Zhao S, Venkatasubbarao K, Lazor JW, et al. Inhibition of STAT3 Tyr705 phosphorylation lay Smad4 suppresses transforming growth factor β-mediated invasion and metas- tasis in pancreatic cancer cells [J]. Cancer Res, 2008, 68 (11):4221-4228.
-
1汪清铭,吴祥元.弥漫大B细胞淋巴瘤的分子异质性[J].国外医学(内科学分册),2005,32(8):353-356. 被引量:1
-
2魏建国,许春伟.采用新一代测序技术分析头颈部鳞状细胞癌的分子异质性[J].临床与实验病理学杂志,2014,30(9):1047-1047. 被引量:2
-
3刘艳艳,李玉富,杨树军,宋永平.弥漫大B细胞淋巴瘤个体化治疗重要研究进展:第54届美国血液学会年会报道[J].白血病.淋巴瘤,2013,22(2):71-73. 被引量:2
-
4于建刚(综述),林德馨(审校).乳腺癌基因表达谱研究进展[J].国际肿瘤学杂志,2010,37(4):290-293.
-
5王海,冷冬妮,周晓军.乳腺癌的基因分型及基底细胞样型乳腺癌[J].肿瘤防治研究,2010,37(7):852-854. 被引量:1
-
6梁树辉,丁杰,郅敏,林涛,吴开春,樊代明.肿瘤血管内皮细胞异质性分子的研究进展[J].现代肿瘤医学,2006,14(1):103-105. 被引量:3
-
7刘宇宏,李晓勇,张王刚.慢性淋巴细胞白血病的遗传基础[J].医学综述,2015,21(13):2329-2332.
-
8王云生,张清媛.三阴型乳腺癌靶向治疗研究进展[J].新乡医学院学报,2016,33(9):815-818. 被引量:5
-
9黄薇,孙关林,李秀松,曹琪,陆雁,王振义,陈竺,陈赛娟.逆转录酶/聚合酶链反应检测早幼粒细胞白血病PML-RARα融合基因对预后和微量残留白血病细胞检测的意义[J].中华血液学杂志,1994,15(1):3-5. 被引量:15
-
10肿瘤免疫学与血清学[J].国外科技资料目录(医药卫生),1997(10):111-111.