摘要
目的探讨胃癌患者血浆血管内皮生长因子(VEGF)和白细胞介素-6(IL-6)水平的变化及其与胃癌临床病理学特征的关系。方法应用酶联免疫吸附法测定68例胃癌患者血浆VEGF及IL-6水平,结合临床病理学资料进行分析。结果胃癌患者血浆VEGF和IL-6水平均显著高于对照组(P<0.01),VEGF、IL-6水平与肿瘤大小、血管侵犯、淋巴结受累及肝脏转移密切相关(P<0.05);随着临床病理分期的升高,VEGF及IL-6水平亦明显升高(P<0.05)。血浆VEGF及IL-6水平与肿瘤组织学类型及患者的性别、年龄等因素无关(P>0.05),血浆VEGF、IL-6之间成正相关(P<0.05)。结论血浆VEGF、IL-6水平与胃癌浸润、转移等有关。联合检测血浆VEGF、IL-6对胃癌的诊断、疗效判断等有一定的价值。
Objective To explore the changes of plasma vascular endothelial growth factor（VEGF） , IL-6 and relationship between them and clinicopathologieal characters in gastric cancer patients. Methods Sixty-eight cases of gastric carcinoma and 40 normal controls plasma samples were measured by enzme- linked immunosorbent assay（ELISA）. Results The plasma levels of VEGF and IL-6 in gastric carcinoma patients were significantly higher than those in the healthy controls. VEGF and IL-6 concentrations were higher in the patients with bigger tumor; venous invasion; lymph node or liver metastasis. The plasma levels of VEGF and IL-6 in the patients in stage III and stage IV were higher than that in stage I and stage II. No correlations had been found among the VEGF and IL-6 eoncertrations with the types. Conclusion The VEGF and IL-6 are associated with tumor progress. Measurement of plasma VEGF and IL-6 might be useful as biomarkers, and can provide a predictor for invasion, metastasis and prognosis, and VEGF and IL-6 might play an important role of evolution in gastric carcinoma.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2009年第6期1123-1125,共3页
Suzhou University Journal of Medical Science
