摘要
目的探讨老年慢性阻塞性肺疾病(COPD)患者血清甲状腺激素水平的变化及其临床意义。方法选择40例急性加重期及稳定期老年COPD患者为研究对象,30例年龄匹配的健康体检者为对照组。应用化学发光免疫分析法测定血清甲状腺激素(TT3、TT4、FT3、FT4)及促甲状腺激素(TSH)水平。并测定动脉血气分析水平。结果COPD急性加重期患者血清TT3水平显著低于稳定期患者及对照组(P<0.05),缓解期患者TT3水平与对照组比较差异无显著性意义(P>0.05)。急性加重期患者TT3与PaO2呈显著正相关(P<0.05)。结论老年COPD急性加重期患者血清TT3水平低于同年龄健康对照组,测定血清TT3水平对COPD患者病情判断及其预后估计具有一定临床参考价值。
Objective To investigate the alteration and clinical significance of serum thyroid hormone levels in senile patients with chronic obstructive pulmonary disease （COPD）. Methods The serum thyroid hormone（total thyroxine, TT4; total triiodothyronine, TT3; free triiodothyronine, FT3; free thyroxine, FT4） and thyroid stimulating hormone （TSH） for 40 senile patients with COPD, either in the acute exacerbation phase or stable phase, and thirty agematched healthy subjects were detected in the method of chemiluminescence immunoassay. At the same time, the bloodgas analysis of aterial blood was determined. Results The difference of serum TT3 between cases of COPD in acute exacerbation phase and controls had a statistical significance （P〈0. 05）, while that in the stable phase and controls did not （P〈0.05）. Besides, TT3 was positively correlated with PaO2 in the acute exacerbation phase of COPD patients （P〈 0.05）. Conclusions Compared with age-matched normal controls, the serum TT3 levels in patients of senile COPD with acute exacerbation are significantly lower, which may be valuable for determining the condition and predicting the progno- sis.
出处
《西部医学》
2010年第4期639-641,共3页
Medical Journal of West China
关键词
慢性阻塞性肺疾病
甲状腺激素
对照
Chronic obstructive pulmonary disease
Thyroid hormone
Control
