摘要
目的制备5-氟脲嘧啶壳聚糖缓释微球并观察其体外缓释药物的作用。方法采用乳化-化学交联法制备5-氟脲嘧啶壳聚糖缓释微球,观察该微球的形态、粒径、药物包封率和在体外药物缓释作用。结果5-氟脲嘧啶壳聚糖缓释微球的平均粒径为(185.5±15.0)nm,包封率为(49.3±2.1)%,在pH7.4PBS缓冲溶液中对5-氟脲嘧啶的累计释放率第1天为(61.6±1.8)%,第3天为(78.2±1.6)%,第7天为(90.5±1.4)%。结论所制备的5-氟脲嘧啶壳聚糖缓释微球具有良好的药物包封率和体外释放作用,符合缓释药物的制备要求。
Objective To prepare 5-fluorouracil loaded chitosan sustained-release microspheres and to observe the role of sustained-release drugs in vitro.Methods The microspheres were prepared using emulsified-chemical cross-linking method and were studied the microspheres morphology,particle size,drug encapsulation efficiency and the role of drug release in vitro.Results The average particle size of the microspheres was （185.5 ± 15.0）nm,encapsulation efficiency was （49.3±2.1）%,in pH 7.4 PBS buffer solution the cumu lative release percentage of 5-fluorouracil released from microspheres was（61.6±1.8）% on the first day,（78.2±1.6）% on the third day,and（90.5±1.4）% on the seventh day.Conclusion The system of 5-fluorouracil loaded chitosan sustained-release microspheres has good encap-sulation efficiency of drugs and release effect in vitro,consistent with sustain-ned-release preparation of drugs required.
出处
《实用临床医学（江西）》
CAS
2010年第3期4-6,F0003,共4页
Practical Clinical Medicine
基金
江西省教育厅资助课题(S00195)
关键词
5-氟脲嘧啶
壳聚糖
微球
缓释作用
5-fluorouracil
chitosan
microspheres
sustained-release effect
