摘要
目的:探讨拉莫三嗪合并抗精神病药,治疗精神分裂症阴性症状的疗效与安全性。方法:对以阴性症状为主的精神分裂症患者50例,按入院顺序随机分为抗精神病药物合并拉莫三嗪组,(合用组)和单用抗精神病药物组(单用组),疗程12周。采用阳性与阴性症状量表(PANSS)评定疗效,用治疗中出现的症状量表(TESS)评定不良反应,于治疗前及治疗4、8、12周各评定一次。结果:合用组显效率64%,单用组显效率40%,从治疗4周起,合用组PANSS总分及阴性症状分均显著低于单用组。结论:以阴性症状为主的精神分裂症患者,在使用抗精神病药物同时联用拉莫三嗪,可改善阴性症状,两组不良反应无明显差异。
Objective： To explore the efficacy and safety of antipsyehotics comhined with lamotrigine in the treatment of schizophrenia with negative symptoms. Method： Fifty eases of schizophrenia mainly with negative symptoms were randondy divided into combined group（ treated with antipsyehotics and lamotrigine） and control group（treated with antipsyehotics）. The course of treatment was twelve weeks. The efficacy and side effects were evaluated by positive and negative symptoms scale （PANSS） and treatment emergent symptoms scale（TESS） before and after treatments for 4,8,12 weeks. Results：The significant improvement rate was higher in the combined group（64% ） than in the control group （40% ）. After 4 weeks treatment,the total scores and negative symptoms scores of PANSS significantly decreased in the eomhined group than in the control group There were no significant differences in side effects between two groups. Conclusion： Antipsychotics combined with lamotrigine can improve the negative symptoms of schizophrenia .
出处
《临床精神医学杂志》
2010年第2期117-118,共2页
Journal of Clinical Psychiatry
