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低拷贝模板DNA分型及其在法医学中的应用 被引量:6

Low Template DNA Profiling and Its Application in Forensic Science
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摘要 近年来,低拷贝模板类生物物证在法庭科学领域中的应用越来越广泛。然而由于其自身存在的一些限制性因素,始终是法庭科学工作者关注的一个焦点。本文从低拷贝模板DNA的定义及其在法庭科学应用中的有效性、应用范围、分型策略、质量控制、重复性原则、随机阈值等方面对低拷贝数分型及其在法庭科学应用中的最新研究进展进行了综述。 Low template DNA(LTDNA) has been widely applied in the fiend of forensic science in recent years. However, the application of low copy number(LCN) analysis is still controversial in certain forensic casework because of its inherent limiting factors. This paper focus on the definition of LCN and LTDNA, the validity and application of LCN in forensic science, methods of typing, quality control, replicate analy- sis, detection thresholds and then reviews the latest development of LCN in forensic science.
出处 《法医学杂志》 CAS CSCD 2010年第2期132-136,共5页 Journal of Forensic Medicine
关键词 法医遗传学 模板 遗传 综述【文献类型】 低拷贝数 forensic genetics templates, genetic review[publication type] low copy number
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  • 1Giardina E,Pietrangeli I,Martone C,et al.Whole genome amplification and real-time PCR in forensic casework[J].BMC Genomics,2009,10:159.
  • 2Budowle B,Eisenberg AJ,van Daal A.Validity of low copy number typing and applications to forensic science[J].Croat Med J,2009,50(3):207-217.
  • 3Gill P,Whitaker J,Flaxman C,et al.An investigation of the rigor of interpretation rules for STRs derived from less than 100pg of DNA[J].Forensic:Sci Int,2000,112(1):17-40.
  • 4Budowle B,Hobson DL,Smefick JB,et al.Low copy number-consideration and caution[C]//Genetic Identity Conference Proceedings,Twelfth International Symposium on Human Identification,Promega Corporation,Madison,Wisconsin,2001.
  • 5van Oorschot RA,Jones MK.DNA fingerprints from fingerprints[J].Nature,1997,387(6635):767.
  • 6Summers C.How science caught up with killer[N/OL].(2001-08-24).http://news.bbc.co.uk/l/hi/uk/1459056.stm.
  • 7Graham EA.DNA reviews:low level DNA profiling[J].Forensic Sci Med Pathol,2008,4(2):129-131.
  • 8Gill P.LCN DNA:proof beyond reasonable doubt? -a response[J].Nat Rev Genet,2008,9(9):726.
  • 9Weir J.In the crown court sitting in Northern Ireland[EB/OL].(2007-12 -20).http://www.xproexperts.co.uk/newsletters/feb08/R%20v%20Hoey.pdf.
  • 10Caddy B,Taylor GR,Linacre AMT.A review of the science of low template DNA analysis[EB/OL].(2008-04-11).http://www.denverda.org/DNA_Documents/Review%20of% 20the% 20Science% 20of% 20Low% 20Template%20DNA%20Analysis.pdf.

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