摘要
目的探讨复方芩柏颗粒治疗大鼠放射性皮炎的机制。方法建立大鼠度放射性皮炎模型,随机分为3组,分别给予复方芩柏颗粒喷雾伤口(实验组)、地塞米松软膏外涂(传统组)及生理盐水喷雾处理(对照组)。通过免疫组化染色及图像分析,测定各组伤后2、6、10、18、24d的创面肉芽组织、创面愈合率及创面组织中碱性成纤维细胞生长因子(bFGF)的表达。结果实验组肉芽组织平均数及创面愈合率在伤后6、10、18、24d各时间点均较对照组及传统组高,差异有统计学意义(P<0.01或P<0.05);bFGF的表达在6、10、18d时亦高于对照组及传统组(P<0.05)。结论复方芩柏颗粒对大鼠度放射性皮炎有一定治疗作用,其机制之一可能与促进创面组织的bFGF表达有关。
Objective To study the mechanism of the Compound Qinbai Granule （Granules composed of Scutellaria root and Phel- lodendron bark） in the treatment of radioactive dermatitis in rats. Methods The rat models of radioactive dermatitis were established and randomized into three groups： Compound Qinbai Granule group （experimental group）, dexamethasone ointment group （traditional group）, and normal saline group （control group）. The wound was treated with Compound Qinbai Granule spray, dexamethasone oint- ment external application, and normal saline spray respectively. By immunohistochemieal staining and image analysis, the growth of granulation tissue in the wound area wound healing rate, and the expression of basic fibroblast growth factor （bFGF） in the wound tis- sues were determined on the second, sixth, tenth, eighteenth, and twenty-fourth day after injury. Results The average number of granulation tissue and wound healing rate in the experimental group on the sixth, tenth, eighteenth, and twenty-fourth day were all higher than those in the traditional group and control group with a significant difference （P〈0.01 or P〈0.05）. The expression of bFGF in the experimental group on the sixth, tenth, eighteenth day was also higher than that in the control group and traditional group （P〈0. 05）. Conclusion Compound Qinbai Granule is effective for the radioactive dermatitis of rats, its mechanism may be re- lated with the promotion of the bFGF expression in the wound area.
出处
《中医杂志》
CSCD
北大核心
2010年第3期265-267,共3页
Journal of Traditional Chinese Medicine
基金
衡阳市2007年社会发展科技支撑计划资助项目(2007KS21)
关键词
复方芩柏颗粒
放射性皮炎
创面愈合
碱性成纤维细胞生长因子
Compound Qinbai ＇Granule （Granules composed of Scutellaria root and PheUodendron bark）
Radioactive dermatitis
Wound healing
basic fibroblast growth factor （bFGF）
