摘要
目的检测原发性肝癌(PLC)经导管动脉化疗栓塞(TACE)治疗前后血清缺氧诱导因子-1α(HIF-1α)及血管内皮细胞生长因子(VEGF)的含量,探讨其与TACE疗效及肿瘤复发、转移之间的相关性。方法40例PLC患者接受TACE治疗前、术后1天、1周、1个月接受血清HIF-1α、VEGF含量检测,对照组为20名健康体检者。结果40例PLC患者TACE术前血清HIF-1α、VEGF含量为(154.94±83.29)pg/ml、(264.00±148.10)pg/ml,明显高于对照组(P<0.01);术后1天为(570.64±230.87)pg/ml、(362.07±102.25)pg/ml,较术前明显升高(P<0.01);术后1周为(198.62±92.11)pg/ml、(283.52±145.46)pg/ml,较术后1天明显下降;术后1个月完全缓解(CR)组患者血清HIF-1α、VEGF含量为(133.96±57.02)pg/ml、(150.96±84.89)pg/ml,较术前明显降低,其中VEGF的含量差异有统计学意义(P<0.05),而部分缓解(PR)和稳定(SD)组患者血清HIF-1α、VEGF含量为(255.74±123.44)pg/ml、(368.95±161.90)pg/ml,较术前明显升高(P<0.05)。PLC患者术前血清HIF-1α与VEGF含量呈正相关,血清HIF-1α与门静脉癌栓形成及肿瘤转移密切相关(P<0.05);血清VEGF的含量与肿瘤临床分期、门脉癌栓及有无包膜密切相关。结论通过检测PLC患者TACE治疗前后血清HIF-1α、VEGF含量,能为评估TACE疗效及判断肿瘤有无复发、转移等提供重要参考依据。
Objective To investigate the expression and correlation of serum hypoxia inducible factor-1α（HIF-1α） and vascular endothelial growth factor（VEGF） level pre-and post-transcatheter arterial chemoembolization（TACE） in patients with primary liver cancer（PLC）.Methods Expression of serum HIF-1α and VEGF were studied in 40 patients of PLC pre-and 1 day,1 week,1 month post-TACE and 20 healthy volunteers（as control group）.Results The expression of HIF-1α and VEGF was（154.94±83.29） pg/ml and（264.00±148.10） pg/ml before TACE,higher than those in control group（P〈0.01）.The expression of HIF-1α and VEGF was（570.64±230.87） pg/ml and（362.07±102.25） pg/ml in PLC patients 1 day post-TACE,higher than those before TACE（P〈0.01）;（198.62±92.11） pg/ml,and（283.52±145.46） pg/ml 1 week post-TACE;（133.96±57.02） pg/ml and（150.96±84.89） pg/ml in the complete response（CR） group 1 month after TACE,（255.74±123.44） pg/ml and（368.95±161.90） pg/ml in partial response（PR） and stable disease（SD） group（P〈0.05）.The expression of serum HIF-1α was positively correlated with VEGF before TACE,and the serum HIF-1α also correlated with portal vein tumor thrombosis and metastasis.Serum VEGF was also correlated with clinical stage,portal vein tumor thrombosis and capsule.Conclusion The expression of serum HIF-1α and VEGF plays an important role in relapse of tumor,and contributes to the evaluation of the efficacy of TACE and metastasis of PLC.
出处
《中国介入影像与治疗学》
CSCD
2010年第2期117-120,共4页
Chinese Journal of Interventional Imaging and Therapy
关键词
肝肿瘤
经导管动脉化疗栓塞
缺氧诱导因子-1Α
血管内皮细胞生长因子
Liver neoplasms
Transcatheter arterial chemoembolization
Hypoxia-inducible factor 1
alpha subunit
Vascular endothelial growth factor
