摘要
目的:观察和探讨血清C反应蛋白(CRP)检测在急性脑梗死患者中的临床应用和意义。方法:用免疫比浊法检测116例急性脑梗死患者的CRP浓度变化并与正常对照组(69例)比较;然后按病程观察CRP的动态变化并与对照组比较;再后进行急性脑梗死轻、重型及大梗死灶型、腔隙性梗死的组间比较,并与对照组比较。结果:急性脑梗死组于发病第3天CRP浓度升高达最高值,与对照组比较,差异非常显著(P<0.01),发病第28天,CRP降至基本正常水平,但仍高于对照组(P<0.05);重型急性脑梗死患者与轻型患者的CRP浓度升高幅度有明显差异(P<0.05),前者于第28天降至接近正常水平,但仍高于对照组(P<0.05)及轻型组(P<0.05);急性脑梗死大梗死灶型较腔隙性梗死患者CRP浓度高,有显著差异(P<0.05),大梗死灶组与对照组比较差异非常显著(P<0.01),第28天前者即使处于恢复期,其CRP水平仍高于腔隙性梗死组及对照组(P<0.05)。结论:CRP是组织损伤和炎性反应的敏感指标,血清CRP水平的实验室检测有助于急性脑梗死病情程度、病灶范围及预后的判断,是值得临床推荐的重要生物学指标。
Objective： To observation and analysis clinic application and significant on laboratory test of serum C-reactive protein（CRP） levels in patients with acute cerebral infarction （ACI）. Methods： The changes of serum CRP concentrations measured by irnmunoturbidimetry in 116 patients with ACI and its were compared with the control group（69 cases） ; and then according to the course of disease, to observe dynamic changes of CRP and its were compared with control group;after that compared the difference between groups;mild ACI and severe ACI, large area infarct ACI and lacunar infarct, and then its were compared with control group at the end. Results;Concentration of CRP reached the peak value in third day of incidence, there were more statistical significance （P〈0. 01）and it were compared with the control group. CRP level fell to near normal level in the 28th day of incidence but it was still on higher level than the control group（P〈0. 05）;CRP levels of the severe ACI and mild ACI clearly raised, but there were obvious difference（P〈 0. 05） between the two groups, the CRP concentration of severe ACI group fell to near normal level in the 28th day of incidence, but it was still＇higer than the control group（P〈0. 05） and mild ACI group（P〈0. 05） ;CRP concentration of patients with the large area infarct ACI were on higher than that of the lacunar group, there were obvious difference（P 〈0. 05）, there were more statistical significance between the large area infarct ACI group and the control group（P〈 0.01） ,in the 28 days of incidence, the former even in recovery CRP level were still higher than the lacunar infarct group （P〈0. 05） and the control group（P〈0. 05）. Conclusion： CRP is a sensitive indicator to reflect tissue damage and inflammation response. The laboratory test of serum CRP levels were to contribute judgement severity of pathological changes, focus range and prognosis assessment. It is a important biological indicator,and it＇s worthy recommending in clinic.
出处
《医学理论与实践》
2010年第4期373-374,379,共3页
The Journal of Medical Theory and Practice
关键词
急性脑梗死
C反应蛋白
检测
Acute cerebral infarction, C-reactive protein, Test
