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雷帕霉素单药及联合硼替佐米、柔红霉素对白血病细胞株抗肿瘤效应的研究 被引量：7

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摘要 雷帕霉素是大环内酯类抗生素，因其强效的免疫抑制和抗细胞增殖活性，主要用于器官移植后急性排斥反应的防治。近年来研究发现血液肿瘤细胞存在P13K／AKT／mTOR信号通路的激活，而雷帕霉素能特异性结合并抑制rnrrOR的活性，导致肿瘤细胞周期阻滞和细胞凋亡，
作者 杨曦 龚玉萍 杨雷 周睿卿 邢宏运 郑波慧
机构地区 四川大学华西医院血液科、血液病研究室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2010年第3期201-203,共3页 Chinese Journal of Hematology
基金 国家自然科学基金（30770912） 四川省科技厅社会公益项目（2008SZ0017） 教育部回国留学人员启动金（20071108-18-4）
关键词 抗肿瘤效应 雷帕霉素 白血病细胞株 硼替佐米 柔红霉素 大环内酯类抗生素 P13K/AKT 细胞增殖活性
分类号 R965 [医药卫生—药理学] R733.7 [医药卫生—肿瘤]
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参考文献8

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二级参考文献24

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共引文献126

同被引文献42

  • 1赵维莅,陈赛娟.砷剂治疗白血病-人类肿瘤靶向治疗的新模式[J].中华医学杂志,2005,85(7):439-440. 被引量：5
  • 2常明,指导,何金森.丹参酮ⅡA对心血管影响的研究进展[J].河南中医,2006,26(1):85-87. 被引量：37
  • 3任传增,许戈良,荚卫东.雷帕霉素抑制肿瘤血管生成的研究进展[J].国际外科学杂志,2007,34(8):547-549. 被引量：4
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中华血液学杂志
2010年 第3期

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