摘要
目的:探讨血清高尔基体蛋白73(Golgi protein 73,GP73)联合AFP对原发性肝癌(PHC)的早期诊断价值。方法:本文共收集160例血清,其中PHC患者64例,肝硬化患者46例,健康人50例。应用ELISA定量检测血清GP73水平,电化学发光免疫分析检测血清AFP水平。结果:GP73诊断PHC的敏感性达到81.2%,与本文患者AFP的敏感性(63.5%)相比,前者有显著增高。GP73和AFP两者联检敏感性有显著提高,达95.3%,与单一GP73或AFP相比敏感性有显著差异(P<0.01),而特异性无显著差异(P>0.05)。结论:血清GP73可能是诊断PHC一个血清标志物,联检血清GP73和AFP对PHC的早期诊断具有良好的临床应用价值。
Objective To investigate the clinical value of combined determination of serum tumor marker Golgi protein 73 （GP73） and alphafetoprotein （AFP） for early diagnosis of liver cirrhosis and PHC. Methods Serum GP73 （with ELISA） and AFP （with ECLIA） levels were determined in 64 patients with PHC,46 patients with cirrhosis of liver and 50 controls. Results The sensitivity of GP73 for diagnosis of PHC was 81.2%,being significantly highter than that of AFP （62.5%）. The sensitivity of combined examnination of GP73 and AFP was 95.3% and was significantly highter than that of single GP73 or AFP test （P0.05）,but the specificity of combined examniation was only slightly lower （P0.05）. Conclusion These results suggest that GP73 may be used as a serum marker for the diagnosis of PHC. Combined determination of serum GP73 and AFP is valuable for the early diagnosis of PHC.
出处
《放射免疫学杂志》
CAS
2010年第2期205-206,共2页
Journal of Radioimmanology
