摘要
目的观察健脾化痰祛瘀中药联用干扰素对慢性乙型病毒性肝炎合并脂肪肝患者抗病毒疗效的影响。方法将64例慢性乙型病毒性肝炎合并脂肪肝患者随机分对照组和治疗组,对照组用干扰素治疗(长效或短效),治疗组在对照组基础上加用健脾化痰祛瘀中药治疗。治疗前后分别进行体重、腰围、臀围、肝功能、血脂、乙型肝炎病毒血清学标志物和HBVDNA定量、超声学检查,治疗6个月后评估疗效。结果治疗组血脂、体重指数及腰臀比均明显降低,治疗后两组比较,差异有统计学意义(P<0.05);治疗组脂肪肝的好转率明显升高,两组比较差异有统计学意义(P<0.05);治疗组抗病毒有效率明显升高,两组比较差异有统计学意义(P<0.05)。结论健脾化痰祛瘀中药能显著改善慢性乙肝合并非酒精性脂肪肝患者的脂肪肝程度,并能提高干扰素对该类患者的抗病毒疗效。
Objective To evaluate the impacts of herbal medicine for strengthening spleen,resolving phlegm and removing stasis（hereinafter referred to＂herbal medicine＂）in combination with interferon on the anti-viral effect for chronic hepatitis B complicated with non-alcoholic steatohepatitis（NASH）.Methods 64 patients with chronic viral hepatitis B complicated with NASH were randomly divided into control group and treatment group.In control group,interferon was administered（long-term effect or short-term effect）.In treatment group,on the basis of the treatment as control group,the herbal medicine was added.Before and after treatment,the body mass,waist and hip circumferences,liver function,blood-lipid level,HBV marker,serum level of HBV DNA and ultrasonographic image index were measured separately.The assessment of efficacy was done 6 months after treatment.Results In treatment group,blood lipid level,BMI and ratio of waist and hip decreased apparently.In comparison of the indexes between two groups after treatment,the difference was significant statistically（P0.05）.In treatment group,the improvement rate of fatty liver increased apparently,indicating significant difference statistically in comparison of two groups（P0.05）.In treatment group,the effective rate of anti-virus increased apparently,indicating significant difference statistically in comparison of two groups（P0.05）.Conclusion The herbal medicine for strengthening spleen,resolving phlegm and removing stasis improves significantly in the degree of fatty liver in chronic hepatitis B patients complicated with NASH,and it can improve the anti-viral efficacy of interferon for those patients.
出处
《世界中西医结合杂志》
2010年第3期222-224,共3页
World Journal of Integrated Traditional and Western Medicine
关键词
健脾化痰祛瘀中药
干扰素
慢性乙型肝炎
非酒精性脂肪肝
Herbal Medicine for Strengthening Spleen
Resolving Phlegm and Removing Stasis
Interferon
Chronic Hepatitis B
Non-Alcoholic Ateatohepatitis（NASH）
