摘要
糖尿病视网膜病变(DR)是糖尿病严重的微血管并发症之一,其发生发展不仅与疾病的病程和血糖的控制情况有关,还表现出明显的家族聚集性和个体差异现象,这可能与遗传因素影响和遗传易感性的不同有关。DR是一个多基因作用的疾病,而每个基因存在不同的多态性。准确把握基因在DR发生发展过程中的作用机制及其表达的差异性,对今后早期诊断和防治DR的发生发展及提供新的诊疗手段具有重要意义。就有关DR相关基因的研究进展进行综述。
Diabetic retinopathy（DR） is one of the most serious complications of diabetes.Studies revealed that the development of DR depend on not only duration of diabetes and level of blood glucose but also positive family history and individual diversities.This phenomenon may be related to various genetic polymorphisms and individuals.DR is a disease of the role of multi-gene,and therefore there is different polymorphisms in each gene.It is very important for us to accurately understand the mechanism of the difference expression of gene during the occurrence and development of DR in the early diagnosis and prevention of DR.The current research advance in DR relevant gene is reviewed in this article.
出处
《眼科研究》
CSCD
北大核心
2010年第4期375-379,共5页
Chinese Ophthalmic Research
