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孕妇甲状腺过氧化物酶抗体及促甲状腺素筛查102例结果分析 被引量:2

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摘要 目的探讨妊娠早期孕妇甲状腺过氧化物酶(TPOAb)及促甲状腺激素(TSH)筛查在发生自身免疫性甲状腺疾病功能紊乱诊断中的临床价值。方法102例孕妇按TPO定性检测结果分为TPOAb阳性组29例和TPO-Ab阴性组73例,按临床诊断标准分为甲状腺功能紊乱组(Ⅰ组)35例,和非甲状腺功能紊乱组(Ⅱ组)67例,采用电化学发光法检测对102例孕妇进行血清TPOAb检测,同时用化学发光法检测TSH。结果Ⅰ组TSH异常率、TSH水平均高于Ⅱ组,TPOAb水平高于Ⅱ组,差异均有统计学意义(P<0.05),TPOAb阳性组TSH<0.35MU/L或>5.50MU/L高于TPOAb阴性组,差异均有统计学意义(P<0.05)。结论TPOAb阳性孕妇甲状腺功能紊乱明显增加,TPOAb阳性孕妇甲状腺功能有向亚临床甲状腺功能减退的趋势。
出处 《临床合理用药杂志》 2010年第8期68-69,共2页 Chinese Journal of Clinical Rational Drug Use
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参考文献6

  • 1Lazarus JH, Thyroid disease in pregnancy and childhood [ J ]. Minerva Endocrinol,2005,30 (2) : 71 - 87.
  • 2Roti E, Uberti. Post partum thyroiditis a clinical update[ J]. Eur J Endocrinol,2002,146 (3) :275 - 279.
  • 3Ghafoor F, Mansoor M, Malik T, et al. Role of thyroid peroxidase antibodies in the outcome of pregnancy[ J]. J Coil Physicians Surg Pak,2006, 16(7) :468 -471.
  • 4Kutteh WH, Yetman DL, Carr AC, et al. Increased prevalence of antithyreid antibodies identifiel in women with recurrentpregnancy loss but not in women undergoing assisted reproduction [ J ]. Fertil Steril, 1999,71 (5) :843 -848.
  • 5曾智杰,姜傥,欧阳文婷,廖慧芳,陈莹,刘敏.过氧化物酶抗体在妊娠甲状腺功能紊乱发生中的诊断价值[J].国际检验医学杂志,2006,27(3):199-202. 被引量:19
  • 6Zubain B,Pierre C, Berruud CD, et al. Laboratory medicine pract guidelines [ J ]. Thyroid,2003,13 : 123 - 126.

二级参考文献10

  • 1Peleg D,Cada S,Peleg A,et al.The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis.Obstet Gynecol,2002,99(6):1040-1043.
  • 2Premawardhana LD,Parkes AB,John R,et al.Thyroid peroxidase antibodies in early pregnancy:utility for prediction of postpartum thyroid dysfunction and implications for screening.Thyroid,2004,14(8):610-615.
  • 3Brent GA.Maternal thyroid function:interpretation of thyroid function tests in pregnancy.Clin Obstet Gynecol,1997,40(1):3-15.
  • 4Zieleniewski W.Kliniczne implikacje wystepowania przeciwcial przeciwtarczycowych u kobiet w ciazy i w okresie poporodowym.[Clinical implications of occurrence of antithyroid antibodies in pregnant women and in the postpartum period].Przegl Lek,2004,61(8):864-867.
  • 5Lazarus JH.Thyroid disease in pregnancy and childhood.Minerva Endocrinol,2005,30(2):71-87.
  • 6Demers LM,Spencer CA.Laboratory medicine practice guidelines:laboratory support for the diagnosis and monitoring of thyroid disease.Clin Endocrinol(Oxf),2003,58(2):138-140.
  • 7Lazarus JH.Thyroid disorders associated with pregnancy:etiology,diagnosis,and management.Treat Endocrinol,2005,4(1):31-41.
  • 8Hollowell JG,Staehling NW,Flanders WD,et al.Serum TSH,T(4),and thyroid antibodies in the United States population (1988 to 1994):National Health and Nutrition Examination Survey (NHANES III).J Clin Endocrinol Metab,2002,87(2):489-499.
  • 9叶秀兰,时立新,黄绘,马启玲,卢源,杨礼福.正常孕妇垂体-甲状腺轴功能变化的研究[J].中华妇产科杂志,2001,36(9):527-530. 被引量:25
  • 10乔文颖.甲亢妊娠和胎儿甲亢[J].国外医学(内分泌学分册),2002,22(2):90-92. 被引量:10

共引文献18

同被引文献29

  • 1关海霞,李晨阳,李玉姝,范晨玲,滕颖,欧阳煜宏,丛琦,滕卫平.妊娠晚期妇女甲状腺疾病特点及甲状腺自身抗体变化的研究[J].中华妇产科杂志,2006,41(8):529-532. 被引量:39
  • 2中国甲状腺疾病诊治指南编委会.《中国甲状腺疾病诊治指南》.中华医学会内分泌学分会,2008,36.
  • 3Negro R, Formoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab, 2006,91 (7) :2587-2591.
  • 4Casey BM, Dashe JS, Wells CE, et al. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol, 2005,105 ( 2 ) : 239- 245.
  • 5Casey BM, Dashe JS, Wells CE, et al. Subclinical hyperthyroidism and pregnancy outcomes. Obstet Gynecol, 2006, 107 (2 Pt 1 ) : 337-341.
  • 6Abalovich M, Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum:an Endocrine Soci- ety Clinical Practice Guideline. J Clin Endocrinol Metab,2007,92 (8 Suppl) :S1-47.
  • 7Vaidya B, Anthony S, Bilous M, et al. Detection of thyroid dys- function in early pregnancy:universal screening or targeted high- risk case finding. J Clin Endocrinol Metab, 2007,92 ( 1 ) : 203- 207.
  • 8曹小秋,顾猛.孕早期血清β-HCG、E_2、P联合测定及E_2/P比值的临床意义[J].中华全科医学,2008,6(11):1191-1192. 被引量:14
  • 9陈彦彦,滕卫平,单忠艳,李晨阳,周卫卫,高波,尚涛,周佳任,丁彬,马英,武英,刘群,刘伟,于晓会,李佳,王薇薇,李元宾,范晨玲,王红,郭锐,张红梅.妊娠前半期甲状腺功能减退症的临床流行病学调查[J].中华内分泌代谢杂志,2008,24(6):597-600. 被引量:70
  • 10李元宾,滕卫平,单忠艳,张丽,赵亚茹,于晓会,李玉姝,王薇薇,赵云静,华天懿,杨柳,范晨玲,王红,郭锐.妊娠中期妇女亚临床甲状腺异常对后代智力发育影响的研究[J].中华内分泌代谢杂志,2008,24(6):601-604. 被引量:73

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