摘要
目的评价国产长春瑞滨(盖诺)联合顺铂同步放化疗治疗晚期非小细胞肺癌的疗效及毒副反应。方法将96例Ⅲ期NSCLC患者随机分为两组,化放组在放疗时及放疗后进行4周期化疗,化疗用药盖诺25 mg/m^2,在每个周期的第1、8天静脉滴注,顺铂25 mg/m^2第1～3天静脉滴注;单放组行单纯放疗。结果化放组有效率72.5%,单放组有效率为44.4%,化放组的有效率明显高于单放组(P=0.008)。化放组和单放组的1、2年生存率分别为70.6%、29.4%和51.1%、20%,中位生存时间分别为18个月和13个月,两组比较差异有统计学意义(P=0.0407)。结论 NP方案联合同步放疗是治疗晚期非小细胞肺癌的安全有效的治疗方法,值得进一步临床研究。
Objective To evaluate the efficacy and toxicity of homemade vinorelbine （NVB） and cisplatin combined synchronous radiotherapy treatment of advanced non small cell lung cancer. Methods 96 patients with stage Ⅲ non small cell lung cancer were divided randomly into the two groups ： The radiotherapy with concurrent chemotherapy group （ group 1 ） and The radiotherapy alone group （group 2）. The groupl was given toatotal dose of 60 Gy radiotherapy and four cycles of concurrent chemotherapy （ vinorelbine 25 mg/m^2 on Days 1 and 8, cisplatin 25 mg/m^2 on Days from 1 to 3 ）. The group 2 was given toatotal dose of 60GY radiotherapy alone. Results The response rate was 72. 5 % for groupl and 44. 4 % for gruop2, respectively, The efficiency of radiotherapy with concurrent chemotherapy group was significantly higher than radiotherapy alone group （P = 0. 1008 ）. The survival rate at 1 year and at 2 year were 77.39 % ,29.4% in the group 1 and 51.1% ,20% in the group 2 ,the median survival wasl 8 months for the groupl and compared with 13 months for the group 2, respectively （P = 010407）. Conclusion NP regimen combined with concurrent radiotherapy in the treatment of advanced non small cell lung cancer is a safe and effective treatment ,worthy of further clinical research.
出处
《中国医学创新》
CAS
2010年第11期58-60,共3页
Medical Innovation of China
关键词
NP方案
放疗
非小细胞肺癌
NP regimen
Radiotherapy
Non small cell lung cancer
