摘要
目的:研究透射电镜下线粒体功能评分及Gleason评分在预测前列腺癌进展中的价值。方法:2006年10月至2007年3月,选择前列腺癌根治术患者20例,年龄58～79(70.1±1.2)岁,在透射电镜下对前列腺癌上皮的线粒体功能进行评分,评分标准参照Flameng分级;同时分析上述患者的Gleason评分值,Gleason评分2～4分为Ⅰ组,5～7分为Ⅱ组。结果:Ⅰ组的线粒体功能评分为(4.0±0.8)分,Ⅱ组为(2.3±0.6)分,两组比较差异有显著性(P<0.05)。线粒体功能评分值与Gleason值呈负相关(r=-0.793,P<0.05);随访1年,低Gleason评分组(Ⅰ组)死亡率为0(0/8),高Gleason评分组(Ⅱ组)死亡率为50%(6/12),两者差异有显著性(P<0.05)。结论:前列腺癌患者中普遍存在线粒体功能紊乱,在恶性程度较高的患者更为严重。线粒体功能评分协同Gleason评分在预测前列腺癌进展中具有较大的价值。
Objective：To evaluate the mitochondrial function score in combination with Gleason score in predicting the progression of prostate cancer.Methods：This study included twenty 58-79（70.1 ± 1.2）years old patients with prostate cancer treated by radical prostatectomy.The epithelioglandular mitochondrial function scores of the patients were obtained under the transmission electron microscope and assessed according to Flameng grading.Meanwhile,their Gleason scores were analyzed and,based on the scores,the patients were divided into Groups Ⅰ（Gleason score：2-4）and Ⅱ（Gleason score：5-7）.Results：The mitochondrial function score of Group Ⅰ was significantly different from that of Group Ⅱ（4.0 ± 0.8 versus 2.3 ± 0.6,P 0.05）,with a negative correlation with the Gleason score（r =-0.793,P 0.05）.One year follow-up showed a significantly lower mortality in Group Ⅰ（0/8）than in Group Ⅱ（6/12）（P 0.05）.Conclusion：Mitochondrial dysfunction exists in prostate cancer patients,particularly in those with higher malignancy.The mitochondrial function score combined with Gleason score plays a valuable role in predicting the progression of prostate cancer.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第3期220-222,共3页
National Journal of Andrology
基金
上海市卫生局课题(2006056)~~
关键词
前列腺癌
GLEASON评分
线粒体功能评分
透射电镜
prostate cancer
Gleason score
mitochondrial function score
transmission electron microscope
