摘要
目的血清脂蛋白(a)[Lp(a)]浓度升高被认为是冠心病的独立危险因素之一。探讨血脂康对冠心病患者空腹与高脂餐后血清Lp(a)浓度的影响。方法50例病情稳定的冠心病患者,经饮食宣教4周后,进行高脂餐负荷试验(总热量为800kcal,其中脂肪50g)。分别于空腹与餐后2、4、6h采集外周静脉血标本,测定血清Lp(a)浓度。将患者随机分为对照组和血脂康组,各25例。治疗6周后重复上述高脂餐负荷试验并测定血清Lp(a)浓度。结果冠心病患者高脂餐后2、4、6h血清Lp(a)和三酰甘油浓度较高脂餐前显著升高,差异有统计学意义(P<0.05)。经血脂康治疗6周后,血脂康组的空腹与餐后各时间点血清Lp(a)和三酰甘油浓度较对照组显著降低,差异均有统计学意义(P<0.01)。结论冠心病患者高脂餐后血清Lp(a)浓度显著升高,血脂康能有效降低冠心病患者空腹与餐后血清Lp(a)浓度。
Objective Elevated serum lipoprotein (a)[Lp(a)] concentration is regarded as an independent risk factor for coronary heart disease(CHD).To explore the effect of Xuezhikang on fasting and postprandial Lp(a) concentrations in patients with CHD.Methods Fifty CHD patients with stable condition after four-week diet control were recruited for high-fat meal test (the total calorie was 800 kcal,including 50g fat).The peripheral blood samples were collected in the fasting state and at 2,4 and 6h after a high fat meal to test the serum Lp(a) concentration.Then 50 CHD patients were randomly divided as Xuezhikang group and control group,with 25 in each.Then,six weeks later,the high-fat meal test and the assay of serum Lp(a) concentration were repeated.Results The postprandial serum Lp(a) and triglyceride concentrations significantly increased at 2,4 and 6h after a high-fat meal that at baseline (P<0.05).After 6-week treatment with Xuezhikang the postprandial Lp(a) and triglyceride concentrations were significantly decreased in Xuezhikang group than in control group (P<0.01).Conclusion The serum Lp(a) concentration after a high fat meal is remarkably increased in CHD patients,Xuezhikang can effectively reduce the fasting and postprandial Lp(a) concentrations.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第12期1282-1284,共3页
Chinese General Practice
关键词
冠心病
脂蛋白(a)
血脂康
饭间期间
Coronary heart disease
Lipoprotein(a)
Xuezhikang
Postprandial period
