摘要
目的探讨短期胰岛素泵持续皮下输注(CSII)与预混人胰岛素30R常规2次皮下注射对新诊断2型糖尿病患者的疗效差异。方法将110例新诊断2型糖尿病患者随机分为两组,其中CSII组采用CSII诺和灵R治疗;常规2次皮下注射组于早、晚餐前30min皮下注射预混人胰岛素30R治疗,比较治疗后两组血糖达到良好控制所需时间及治疗2周后新诊断2型糖尿病患者的缓解率。结果CSII组和常规2次皮下注射组患者治疗后均可有效降低血糖,CSII组血糖达到良好控制时间明显快于常规2次皮下注射组,两组比较差异有统计学意义(P<0.01)。治疗2周后,停用胰岛素1周,仅使用饮食控制及运动疗法,2型糖尿病患者病情缓解率CSII组明显高于常规2次皮下注射组,两组比较差异有统计学意义(P<0.05)。结论新诊断2型糖尿病患者短期应用CSII胰岛素模式,使血糖达到良好控制的时间短于应用预混人胰岛素30R常规2次皮下注射模式,且2型糖尿病患者病情的缓解率也较高。
Objective To discuss the clinical effect of continuous subcutaneous insulin infusion（CSII） or Novolin 30R on newly diagnosed type 2 diabetic mellitus（T2DM）.Methods One hundred ten T2DM patients were randomly divided into groups CSII （receiving CSII novolin R） and Convention （receiving subcutaneous injection of premixed human insulin-30R,30 min before breakfast,dinner）.The required time that good blood glucose （BG） control was achieved and the remission rate of newly-diagnosed T2DM patients after 2 weeks of treatment were compared between 2 groups.Results Blood glucose were reduced effectively after treatment,the required time that good BG control was achieved was shorter in CSII group than in convention group,the difference was significant （P0.01）.After 2 weeks of treatment,insulin was stopped for 1 week,using only diet control and exercise therapy,the remission rate of CSII group was significantly higher than that of convention group （P0.05）.Conclusion Short-term application of CSII insulin in newly-diagnosed T2DM patients need shorter required time that good BG control is achieved than conventional subcutaneous injection of premixed human insulin-30R,with higher remission rate.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第12期1285-1286,共2页
Chinese General Practice
关键词
糖尿病
2型
胰岛素泵
注射
皮下
Diabetesmellitus
type 2
Insulin pump
Injection
subcutaneous
