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钠氢交换蛋白-1在心血管疾病中的作用分析 被引量：2

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摘要 钠氢交换蛋白(sodium hydrogen exchanger,NHE)是一类存在于细胞膜表面的离子转运泵蛋白家族,NHE-1亚型是NHE家族中最具特征性结构的一类。它负责将细胞内H+与细胞外Na+按照1:1的比例进行交换来调控细胞内pH的动态平衡,从而影响细胞的容积、运动、分化、凋亡、营养吸收以及生长增殖等,进而参与许多复杂的生理和病理过程。本文综述了其在心力衰竭、冠心病、高血压、先天性心脏病以及心律失常等的发生、发展及演变过程中的重要作用。
作者 李静 李新香 孙景辉
机构地区 吉林大学第一医院小儿心血管科 长春中医药大学附属医院儿科
出处 《中国全科医学》 CAS CSCD 北大核心 2010年第12期1364-1366,共3页 Chinese General Practice
关键词 心血管疾病 心力衰竭 高血压
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献29

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二级参考文献13

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共引文献12

同被引文献26

  • 1刘唐威,王秋雁,伍伟锋.内质网伴侣蛋白在小鼠病毒性心肌炎心肌细胞的表达及其与细胞凋亡的关系[J].广西医科大学学报,2005,22(2):157-159. 被引量：9
  • 2Bersinger NA, Frischknecht F, Taylor RN, et al. Basal and cyt0kinestimulated production of epithelial neutrophil activating peptide-78 (ENA-78) and interleukin-8 (IL-8) by cultured human endometrial epithelial and stromal cells [J]. Fertil Steri1,2008,89(5 Suppl) : 1530-1536.
  • 3Qing K, Weifeng W, Fan Y, et al. Distinct differentexpression of Th17 and Th9 cells in coxsackie virus B3- induced mice viral myocarditis [J]. Virol J,2011,8:267.
  • 4Heymans S, Pauschinger M, de Palma A, et aL Inhibi- tion of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis [J ]. Circulation, 2006,114 (6) : 565-573.
  • 5李奋.病毒受体陷阱与病毒性心肌炎[J].临床儿科杂志,2007,25(10):801-804. 被引量：2
  • 6WIEBE C A,RIEDER C,YOUNG P G,et al. Functional anal- ysis of amino of the Na /H exchanger that important for pro- ton translocation[ J]. Mol Cell Biochem,2003,254(1-2) :117- 124.
  • 7LOO S Y,CHANG M K,CHUA C S,et al. NHE-1 :a promising target for novel anti-cancer therapeutics [ J ]. Curr Pharm Des, 2012,18 (10) : 1372-1382.
  • 8房晓伟,李玉光.兔骼动脉球囊损伤后血管平滑肌钠氢交换体蛋白变化及钠氢交换抑制剂对血管狭窄的干预作用[D].广东:汕头大学医学院,2004:1-38.
  • 9TOUYZ R M, SCHIFFRIN E L. Activation of the Na /H ex- change modulates angiotensin 11- stimulated Na - dependent Mg2 transport in vascular smooth muscle cells in genetic hy- pertension [ J]. Hypertension, 1999,34( 3 ) :442-449.
  • 10CINGOLANI H E, REBOLLEDO 0 R, PORTIANSKY E L, et al. Regression of hypertensive myocardial fibrosis by Na /H exchange inhibition[ J ]. Hypertension ,2003,41 (2) :373- 377.

引证文献2

二级引证文献68

中国全科医学
2010年 第12期

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