摘要
Twist是碱性螺旋-环-螺旋（bHLH）录因子家族成员，是上皮间质转化（EMT）过程中的关键调控因子。Twist在胚胎发育及肿瘤的发生发展、侵袭转移过程中发挥重要作用，并与肿瘤耐药密切相关。
The Twist protein is a highly conserved transcription factor that belongs to the family of basic helix-loop-helix proteins. It has been known that Twist is a key regulator of epithelial-mesenchymal transition, and it plays roles in the metastasis and drug-resistant of tumor. Further researches show that Twist could be a new target for cancer therapy.
出处
《国际肿瘤学杂志》
CAS
2010年第2期114-116,共3页
Journal of International Oncology
关键词
TWIST
转录因子
抗药性
肿瘤
肿瘤转移
Twist
Transcription factor
Drug resistance
Neoplasms
Neoplasm metastasis
