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治疗帕金森病的新药:儿茶酚-氧位-甲基转移酶(COMT)抑制剂——托卡朋、安托卡朋 被引量：2

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摘要 80年代末,由Linden首先报道了几种COMT-I,主要有托卡朋(Talcapone)和安托卡朋(Enta-capone).通过大量实验证实托卡朋是一种高效、选择性强和毒副作用少的第二代口服COMT-I,它可以抑制脑内外(肠道和肝脏)的COMT活性,而安托卡朋主要抑制脑外的COMT活性.
作者 曾湘豫 秦斌 王新德
机构地区 卫生部北京医院
出处 《中国临床神经科学》 1998年第4期234-236,共3页 Chinese Journal of Clinical Neurosciences
关键词 震颤麻痹 新药 治疗 托卡朋 安托卡朋
分类号 R742.505 [医药卫生—神经病学与精神病学] R971.6 [医药卫生—药品]
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参考文献5

  • 1Keranen T, Gordin A, Harjola VP, et al. The effect of catcchol-O-methyltransferase inhibition by entacapone on the pharmacokinctics and metabolism of levodopa in healthy volunteers. Clin Neuropharmacol, 1993, 16 :145.
  • 2Linden IB, Nissinen E, Etemadzadeh E, et al. Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parklnson's disease J Pharmacol Exp Ther,1988,247:289.
  • 3Myllyla VV, Jackson M, Larsen JP, et al. Efficacy and safety of tolcapone in levodopa-treated Parkinson's disease pateints with "wearing-off" phenomenon:a a multicentre, double-blind, randomized, placcbo-con-trolled trial. Eur J Neurol, 1993, 4 : 333.
  • 4Rajput AH, Martin W, Saint-Hilaire MH, et al. Tolcapone improves motor function in parkinsonian patioents with the "wearing-off" phenomenon: a double-blind,placebo-control, multicenter trial. Neurology, 1997, 49:l066.
  • 5Roberts JW, Cora-Loeatelli G, Bravi D, et al. Cate-chol-O-methyltransferase inhibitor tolcapone prolongs levodopa/carhidopa action in parkinsonian patients Neurology, 1994, 43 : 2685.

同被引文献15

  • 1丁正同,王坚,邬剑军,蒋雨平,刘楠,张克忠.恩他卡朋添加治疗症状波动的帕金森病的随机、双盲、安慰剂对照临床研究[J].中国临床神经科学,2005,13(1):91-95. 被引量：5
  • 2Zhang HL,Wu JJ,Ren HM,et al.Therapeutic effect of microencapsulated porcine retinal pigmented epithelial cells transplantation on rat model of Parkinson's disease[J].Neurosci Bull,2007,23:137-144
  • 3包新民,舒斯云.大鼠脑立体定向图谱[M].人民卫生出版社,1991:48
  • 4Fang X,Sugiyama K,Akamine S,et al.The stepping test and its learning process in different degrees of unilateral striatal lesions by 6-hydroxydopamine in rats[J].Neuroscience,2006,403-409
  • 5Nishino S,Honda K,Riehl J,et al.Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans[J].Neuroreport,1998,9:3653-3661
  • 6Castro A,Valldeoriola F,Linazasoro G,et al.Optimization of use of levodopa in Parkinson's disease:role of levodopa-carbidopaentacapone combination[J].Neurologia,2005,20:180-188
  • 7Marin C,Aguilar E,Obeso JA.Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats[J].Mov Disord,2006,21:646-653
  • 8Learmonth DA,Palma PN,Vieira-Coelho MA,et al.Synthesis,biological evaluation,and molecular modeling studies of a novel,peripherally selective inhibitor of catechol-O-methyltransferase[J].J Med Chem,2004,47:6207-6217
  • 9Marin C,Aguilar E,Bonastre M,et al.Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats[J].Exp Neurol,2005,192:184-193
  • 10Lautala P,Ethell BT,Taskinen J,et al.The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases[J].Drug Metab Dispos,2000,28:1385-1389

引证文献2

二级引证文献8

中国临床神经科学
1998年 第4期

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