摘要
目的了解医院铜绿假单胞菌耐药性的变迁和现状,并探讨其发展与抗菌药物用量之间的关系。方法采用回顾性调查方法,对5年中10种抗菌药物的年用量进行汇总,计算抗菌药物的年用药频度(DDDs),并用SPSS17.0版统计软件对铜绿假单胞菌的耐药率与抗菌药物年用量进行相关性分析。结果10种抗菌药物的耐药率均呈波动下降趋势;其中只有哌拉西林和头孢他啶的年用药频度呈逐年增长趋势;庆大霉素、左氧氟沙星、美罗培南、头孢吡肟、哌拉西林/他唑巴坦年用药频度与铜绿假单胞菌耐药率差异有统计学意义(P<0.01);哌拉西林、亚胺培南和头孢哌酮/舒巴坦(P<0.05)有相关性;头孢他啶和环丙沙星差异无统计学意义;左氧氟沙星的用药频度与环丙沙星耐药率之间差异有统计学意义(P<0.01)。结论5年铜绿假单胞菌对10种抗菌药物的耐药率呈波动性下降趋势,部分抗菌药物使用量与铜绿假单胞菌耐药水平变化之间存在相关性。
OBJECTIVE To investigate the current situation and ＂the vicissitudes of the resistance of Pseudomonas aeruginosa in our hospital and analyze the relationship between the resistance and the consumption of antibacterial drugs used yearly. METHODS The yearly consumption of 10 antibacterial drugs prescribed in our hospital and the resistance of P. aerugonosa to the 10 antibacterial drugs in the last 5 years were analyzed retrospectively. DDDs were calculated. The relationship between the resistance and the quantity was analyzed using the software of SPSS17.0. RESULTS The resistance rate to 10 kinds of antimicrobial drug was with adownward trend. The annual DDDs of eeftazidime and piperacillin were year-on-year with a growth trend. There were significant differences among the relations between the resistance rate of P. aerugonosa and DDDs of antibacterial drugs except ceftazidime and ciprofloxacin. The resistance rate was significantly related with the use frequency of levofloxacin and ciprofloxaein（P〈0.01）. CONCLUSIONS The resistance rates of P. aerugonosa to the 10 antibacterial drugs have decreased slightly with fluctuation. There is a correlation between the resistance and the yearly consumption of some antibacterial drugs prescribed.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第7期993-995,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
耐药性
相关性分析
Pseudomonas aeruginosa
Drug resistance
Correlation analysis
