摘要
目的了解住院患者中多药耐药鲍氏不动杆菌（MDRAB）的耐药情况和耐药特点,探讨MDRAB感染的危险因素。方法回顾性调查2007年1-12月住院患者中MDRAB与非MDRAB感染的药敏结果,对各种研究因素进行χ^2检验、单因素和多因素非条件Logistic回归分析等,分析各研究因素与MDRAB感染的关系,找出MDRAB感染的危险因素。结果2007年1-12月共检出鲍氏不动杆菌206株,其中多药耐药菌株98株,阳性检出率为47.6%;不同年龄、病区、感染部位MDRAB的阳性率差异有统计学意义（P〈0.05）;MDRAB除头孢哌酮/舒巴坦外,对其余抗菌药物的耐药率均〉70.0%,普遍高于非MDRAB。结论危险因素主要有侵入性操作、≥2种抗菌药物使用〉7 d、免疫抑制剂的应用、白蛋白偏低等,均增加MDRAB感染的机会。
OBJECTIVE To investigate the hospital patients infected by Acinetobacter baumannii and their multidrug-resistence;and study the risk factors of their infection induced by multidrug-resistant A.baumannii（MDRAB）.METHODS A respective study of the clinical data of hospital patients infected by positive MDRAB and negative MDRAB from Jan 2007 to Dec 2007 was conducted by non-conditional Logistic regression analysis.Data were analyzed with chi-square test and unconditional Logistic regression.RESULTS The average positive rate of MDRAB in 206 A.baumanniis strains was 47.6%.Among 98 MDRAB,the ratio of MDRAB in different groups of age was different.The positive rate of multidrug-resistance in different wards and in different infection sites was different.CONCLUSIONS Multidrug-resistance induced by A.baumannii could attribute to multiple factors mainly to invasire operation,unreasonable use of antibiotics,adrenal cortical hormone and immnnodepressants and low albumin.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第8期1059-1061,共3页
Chinese Journal of Nosocomiology
关键词
多药耐药
鲍氏不动杆菌
危险因素
Multidrug-resistance
Acinetobacter baumannii
Risk factors
