摘要
目的为了探讨Y染色体异常及多态性与生殖相关的临床效应。方法对3116例男性不育患者通过取外周血淋巴细胞培养,显带进行染色体核型分析。结果检出Y染色体异常及多态性99例,占全部被检患者的3.17%。Y染色体异常核型7例,占全部被检患者的0.22%,其中Y染色体结构异常5例,占全部被检患者的0.16%,Y染色体数目异常2例,占全部被检患者的0.06%。Y染色体多态性核型92例,占全部被检患者的2.95%,其中Y≥1834例,占全部被检者1.09%,Y≤2152例占全部被检者1.67%。Y染色体臂间倒位6例,占全部被检者0.19%。结论Y染色体异常及多态性能引起各种与生殖有关的临床效应,在遗传咨询工作中应引起足够的重视。
Objective：To study the polymorphism of Y chromosome abnormalities and clinical and reproductive-related effects.Methods：Of the 3116 cases of male infertility in patients with peripheral blood lymphocyte culture through the check,chromosome-banding karyotype analysis.Results：Y chromosome abnormalities were detected and 99 cases of polymorphism,the total was 3.17% in patients with seizure.Y chromosome seven cases of abnormal karyotype,the total was 0.22% in patients with seizure,in which Y chromosome structural abnormalities in 5 cases,the total was found in patients with 0.16% chromosome abnormality in 2 cases,was seized total 0.06% of patients.Y chromosome polymorphism in 92 cases of nuclear type,the total was 2.95% in patients with seizure,in which Y ≥18 34 cases,was seized from the total 1.09%,Y ≤ 21 52 who was seized total 1.67%.Y chromosome pericentric inversion 6 cases,seized from the total 0.19%.Conclusion：Polymorphism of Y chromosome abnormalities and can cause a variety of clinical and reproductive-related effects.In the work of genetic counseling should be given due consideration.
出处
《中国优生与遗传杂志》
2010年第4期61-62,53,共3页
Chinese Journal of Birth Health & Heredity
关键词
Y染色体
异常
多态性
生殖关系
Y chromosome
Anomaly
Polymorphism
Reproductive relations
