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异体输血对食管癌患者IFN-γ mRNA和IL-10 mRNA表达的影响 被引量：6

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摘要 目的观察食管癌患者异体输血对围术期IFN-γmRNA和IL-10 mRNA表达的影响。方法40例中下段食管癌患者在全身麻醉下行食管癌根治术。术中未输血12例(对照组),输异体血28例,其中输入≤2 U浓缩红细胞者15例(观察Ⅰ组),输入≥3 U浓缩红细胞者13例(观察Ⅱ组)。三组分别于麻醉后切皮前(T1)、术后第1天(T2)、第7天(T3)取静脉血10 ml采用RT-PCR法测定IFN-γmRNA和IL-10 mRNA表达。结果IFN-γmRNA和IFN-γmRNA/IL-10 mRNA值:与T1比较,观察Ⅱ组于T2～3、观察Ⅰ组于T2显著降低(P<0.05);组间比较,观察Ⅱ组于T2～3显著低于观察Ⅰ组和对照组,而观察Ⅰ组于T2较对照组显著降低(P<0.05)。IL-10 mRNA:与T1比较,观察Ⅱ组于T2～3、观察Ⅰ组于T2显著降低(P<0.05);组间比较,观察Ⅱ组于T2～3显著高于对照组、于T3显著高于观察Ⅰ组(P<0.05)。结论异体输血可导致食管癌患者术后免疫功能抑制,不利于患者预后。
作者 崔宏先 艾登斌 帅训军 张海荣
机构地区 青岛市市立医院
出处 《山东医药》 CAS 北大核心 2010年第15期80-81,共2页 Shandong Medical Journal
关键词 异体输血 干扰素-Γ 白介素-10
分类号 R735.1 [医药卫生—肿瘤] R457.1 [医药卫生—治疗学]
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参考文献4

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同被引文献45

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引证文献6

二级引证文献19

山东医药
2010年 第15期

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