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糖皮质激素对慢性肾脏疾病患者骨代谢影响的机制及对策 被引量：6

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摘要 在风湿免疫性疾病及器官移植领域，糖皮质激素（GC）应用日益广泛。继绝经后妇女及老年性骨质疏松后，GC诱导的骨质疏松（GIOP）已经成为骨质疏松第三大原因。除了直接减少成骨细胞的数量和活性外，GC还可降低钙在胃肠道的吸收，加速。肾脏钙的排泄，并通过减少性激素分泌、抑制胰岛素样生长因子和前列腺素E2产生以及影响甲状旁腺激素（PTH）等环节导致骨量减少。
作者 王玲 袁伟杰
机构地区 上海交通大学附属第一人民医院肾内科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2010年第3期229-232,共4页 Chinese Journal of Nephrology
关键词 慢性肾脏疾病 糖皮质激素 老年性骨质疏松 骨代谢 胰岛素样生长因子 风湿免疫性疾病 患者 甲状旁腺激素
分类号 R580 [医药卫生—内分泌]
  • 相关文献

参考文献26

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二级参考文献5

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共引文献8

同被引文献59

  • 1张群慧,倪丽.风湿免疫疾病中肺部并发症预防及护理[J].实用医技杂志,2008,15(33). 被引量：10
  • 2陈运生,王德,孙玲玲,陈月生,赵维玲,马祖祥.原发性肾病综合征患儿血清IGF-Ⅰ和血脂变化及相关性研究[J].蚌埠医学院学报,2006,31(4):426-428. 被引量：5
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引证文献6

二级引证文献56

中华肾脏病杂志
2010年 第3期

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