期刊文献+

吉非替尼治疗晚期非小细胞肺癌疗效的相关分子生物学因素研究进展 被引量:2

Molecular Factors Related to Gefitinib Efficacy in Advanced Non-small Cell Lung Cancer
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摘要 非小细胞肺癌(non-small cell lung caner,NSCLC)占肺癌的80%,确诊时多为晚期。虽然手术、化疗、放疗技术在不断提高,但NSCLC患者的预后仍然很差,总体5年生存率仍然小于20%。近年来一些针对肿瘤特定分子靶点的抗肿瘤靶向药物显示了一些疗效,
作者 吕平 周涛
出处 《中国肺癌杂志》 CAS 2010年第3期247-253,共7页 Chinese Journal of Lung Cancer
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参考文献48

  • 1Raben D, Helfrich B, Bunn PAJr. Targeted therapies for non-small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective. IntJ Radiat Oncol Biol Phys, 2004, 59(2 Suppll): 27-38.
  • 2Reck M. Gefitinib in the treatment of advanced non-small cell lung cancer. Expert Rev Anticancer Ther, 2009, 9(4): 401-412.
  • 3Jiang HY. Overview of gefitinib in non-small cell lung cancer: an Asian perspective.JpnJ Clin Oncol, 2009, 39(3): 137-150.
  • 4孙少卫,肖莉,廖端芳.EGFR突变在非小细胞性肺癌发生和化疗反应性中的作用及其分子机制[J].南华大学学报(医学版),2007,35(3):445-448. 被引量:4
  • 5赵向飞,刘晓晴.EGFR酪氨酸激酶区域基因变异与吉非替尼治疗非小细胞肺癌临床因素相关性研究进展[J].现代肿瘤医学,2008,16(8):1438-1441. 被引量:3
  • 6朱红,Tam Yee San Issan,Maria Wong.EGFR突变与非小细胞肺癌酪氨酸激酶抑制剂靶向治疗[J].中国肿瘤生物治疗杂志,2007,14(2):105-109. 被引量:11
  • 7Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small cell lung can- cer to gefitinib. N EnglJ Med, 2004, 350(21): 2129-2139.
  • 8XuJM, Han Y, Duan HOt et al. EGFR mutations and HER2/3 protein ex pression and clinical outcome in chinese advanced non-small cell lung can cer patients treated with gefitinib. J Cancer Res Clin Oncol, 2009, 135(6) 771-782.
  • 9Chan SK, Gullick WJ, Hill ME. Mutations of the epidermal growth factor receptor in non-small cell lung cancer-search and destroy. Eur J Cancer, 2006, 42(1): 17-23.
  • 10Zhu JOa Zhong WZ, Zhang GC, et al. Better survival with EGFR exon 19 than exon 21 mutations in gefitinib-treated non-small cell lung cancer patients is due to differential inhibition of downstream signals. Cancer Lett, 2008, 265(2): 307-317.

二级参考文献191

  • 1BaoMingQIN,XiaoCHEN,JingDeZHU,DuanQingPEI.Identification of EGFR kinase domain mutations among lung cancer patients in China:implication for targeted cancer therapy[J].Cell Research,2005,15(3):212-217. 被引量:66
  • 2吴秋歌,王静.PI3K/AKT抑制剂对人肺癌细胞株生长的影响[J].肿瘤基础与临床,2006,19(2):101-103. 被引量:6
  • 3周彩存,邓沁芳.肺癌分子靶向药物耐药机制的研究进展[J].中华结核和呼吸杂志,2007,30(2):138-140. 被引量:3
  • 4Cappuzzo F, Magrini E, Ceresoli GL, et al. Akt phosphorylation and gefitinib efficacy in patient s wit h advanced non small cell lung cancer. J Natl Cancer Inst,2005,97(6) :461 - 462.
  • 5West KA, Brognard J, Clark AS, et al. Rapid Akt activation by nicotine and a tobacco caricogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest ,2003,111:81 - 90.
  • 6Balsam B R, Pei J, Mit suuchi Y, et al. Frequent activation of AKT in non small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis ,2004,25 ( 11 ) :2053 - 2059.
  • 7Drevs J, Medinger M, Schmidt Gersbach C, et al. Receptor tyrosine kinases:the main targets for new anticancer therapy. Cure Drug Targets, 2003,4:113 - 121.
  • 8Adjei AA. Novel combinations based on epidermal growth factor receptor inhibition. Clin Cancer Res,2006,12(14) :4446 -4450.
  • 9Brognard J, Clark AS, Ni Y, et al. Akt/protein kinase B is constitutively active in non-small cell lung cancer ceils and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res, 2001,61 (10) :3986 - 3997.
  • 10Tang JM, He Q Y, Guo RX, et al. Phosphorylated Akt overex pression and loss of PTEN expression in non small cell lung cancer confers poor prognosis. Lung Cancer,2006,51 (2) :181 - 191.

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