摘要
目的：临床观察大肠癌和癌旁粘膜中胃泌素、生长抑素（ＳＳ）及其分泌细胞的变化，探讨病人体内胃泌素、ＳＳ变化的原因和意义。方法：采用放射免疫法（ＲＩＡ）测定２６例大肠癌病人肿瘤和癌旁粘膜中胃泌素、生长抑素（ＳＳ）水平，并对其分泌细胞行免疫细胞化学观察。结果：肿瘤和癌旁粘膜中胃泌素含量极低且无胃泌素细胞存在。癌远旁粘膜（ＣＤＭ，距肿瘤约５ｃｍ）ＳＳ水平低于癌近旁粘膜（ＣＡＭ，距肿瘤０～２ｃｍ），高于肿瘤，两两相比相差均非常显著（Ｐ＜０．０１）。高分化癌、粘液腺癌组织平均ＳＳ水平高于中分化癌（前者Ｐ＜０．０１，后者Ｐ＜０．０５）和低分化癌（Ｐ＜０．０５）。肿瘤中未见ＳＳ细胞；癌旁粘膜中ＳＳ细胞的形态、位置近于正常。０～２ｃｍ粘膜中ＳＳ细胞数高于４ｃｍ～６ｃｍ粘膜，相差非常显著（Ｐ＜０．０１）；ＣＡＭ中ＳＳ水平与ＳＳ细胞数间呈非常显著之正相关（Ｐ＜０．０１）。结论：ＣＡＭ中ＳＳ上升的主要原因是粘膜中ＳＳ细胞数量增多并分泌大量的ＳＳ。这可能有助于延缓肿瘤的发生、发展，是机体发生于病灶局部的一种防御反应。
Purpose: To explore the reason and significance of the variation of gastrin and somatostatin (SS) in colorectal cancer patients through clinically observing the changes of gastrin, SS and their secretory cells in tumor and its surrounding mucosae. Method: The gastrin. SS levels in tumor and its surrounding mucosa were determined by RIA, and the gastrin, SS secretory cells in these tissues were observed by immunocytochemistry in 26 colorectal cancer patients. Results: Gastrin level in tumor and its surrounding mucosa was too low to be detected and there were no gastrin cells in those tissues. The mean SS level in cancer-distant mucosa (CDM, about 5 cm from the tumor) was very significantly lower than that in cancer-adjacent mucosa (CAM, 0-2 cm from the tumor), and higher than that in tumor (P<0.01). The mean SS levels both in the well differentiated and mucinous adenocarcinomas were significantly higher than those in moderately (P<0.01 and 0.05, respectively) and poorly (P<0.05) differentiated tumors. SS cells were not found in tumor. The form and location of SS cells in all tumor surrounding mucosae were similar to the normal. The mean SS cell number was very significantly higher in adjacent mucosae than in 4-6 cm mucosae (P<0.01). In CAMs, there was a very signifigant positive correlation between the SS levels and SS cell numbers (P<0.01). Conclusions: The elevation of SS level in CAM is mainly caused by the increase of SS cell number, which secrete more SS. The change of SS in colorectal cancer surrounding mucosa maybe play an important role in inhibiting the development of the tumor, and is a local defensive reaction in the body.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1998年第2期87-89,F003,共4页
Chinese Journal of Cancer
