摘要
目的：探讨前列腺上皮内肿瘤（ＰＩＮ）与前列腺癌的关系。方法：用常规ＨＥ染色、免疫组化、电镜方法，对１１３例前列腺标本进行形态学研究。结果：（１）ＰＩＮ由分泌细胞异型增生所致，其１、２级基底细胞及基底膜完整，３级则为局限性缺失和断裂。（２）ＰＩＮ检出率在前列腺癌例中明显高于非癌例中，癌旁高于远癌区，提示与癌关系密切。（３）免疫组化对ＰＩＮ的分级、ＰＩＮ与癌的鉴别有意义。（４）利用电镜观察癌细胞微足状浸润，对前列腺癌的早期浸润和诊断有价值。结论：ＰＩＮ为前列腺的癌前病变。
Purpose To study the relationship between the prostatic intraepithelial neoplasia and prostatic adenocarcinoma. Methods One hundred and thriteen cases of prostatic specimens were studied with routin HE, immunohistochemistry and electronmicroscopy technique. Results (1) The PIN was transformed from the dysplastic proliferation of luminal secretory cells. Acording to its morphologic degrees, it was further divided into three types. In grade 1 and grade 2 intact basal cells(BC) and basement membrane(BM) were present, while in grade 3, some of BC were impaired and the BM were interrupted. (2) The detectable rates of PIN were higher in prostates with carcinoma than in prosates without carcinoma and were higher near the cancer area than distant the cancer area. (3)Immonohistochemistry was very useful for distinguishing PIN from PAC. (4) EM was significanty to make diagnosis on the PAC invasion. Conclusion PIN was a precancerous disease and was closely related to carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第3期219-221,I032,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
前列腺上皮内
基底细胞
基底膜
前列腺癌
prostatic intraepithelial neoplasia
basal cell
basement membrane
prostatic adenocarcinoma
