摘要
本文采用放射免疫分析法,对107例癫痫患者进行了149次血清苯妥英钠(DPH)测定,51例同时进行了血及唾液浓度测定。结果表明,DPH对控制发作的最适血清浓度为13.04±5.96 μg/ml(X±SD),唾液中DPH的有效浓度为1.34±0.67μg/ml,血清浓度约为唾液的10倍,血清浓度与唾液浓度成正相关,测定唾液浓度可代替血清浓度,直接反映游离药物水平,根据DPH浓度可进行药物剂量的调整,指导患者正确用药,对提高疗效有重要意义。
The concentration of diphenylhydantoin(DPH)on serum in 107 cases of epileptic patients and 51 cases which both in serum and salivawere measured by Radio-Immuno-Assay technique. The results showed that the effective concentration in serum for controlling the epileptic attack was 13.04 5.96ug/ml (X±SD), 1.34 0.67ug/ml in saliva respectively, which was one-tenth in saliva that compare to the serum, and it was strongly correlation between both of them.It is suggested that the moni tor of DPH content in epileptic patient is a useful approach for controlling the attack and effective treatment, and finding side effect in early stage. It isa practicalmethod for measurement of DPH from the saliva and can be accepted by patients generally
出处
《青海医学院学报》
CAS
1990年第1期27-29,共3页
Journal of Qinghai Medical College
