摘要
目的:分析系统性淀粉样变临床特点及不同方案治疗情况下的临床疗效,提高对淀粉样变的治疗认识。方法:回顾分析哈医大一院及大庆油田总医院近10年43例淀粉样变药物治疗的临床资料,总结不同临床特点下药物疗效和预后。结果:2组药物有效率分别为54.90%、48.57%,组间无差异性(P>0.05)。原发性淀粉样变和继发性淀粉样变总有效率分别为32.72%、74.19%,组间具有差异性(P<0.05)。不同年龄组间有效率具有差异性(P<0.05)。不同治疗周期有效率无差异性(P>0.05)。不同病变系统有效率分别为单系统75.00%,2个系统45.00%,3个系统29.41%,4个及以上系统5.88%,组间具有差异性(P<0.05)。器官功能代偿期与失代偿期的有效率分别为61.76%、30.76%,组间具有差异性(P<0.05)。结论:药物治疗系统性淀粉样变性具有确切的临床疗效,对继发性淀粉样变的临床疗效优于原发性淀粉样变。药物治疗的最佳周期为6个月以内,延长治疗时间不能提高临床疗效而会增加副作用。随着病变器官和系统的增加及器官功能失代偿,药物疗效降低。
Objective：To analysis system amyloidosis＇s different clinical character and treatment.Methods：43 cases of system amloidosis of our hospital in recent 10 years were retrospectively reviewed.All of the cases were treated by melphalan and hormone or melphalan 、hormone and colchicines.Results：The treatment effectiveness of the two groups was 54.90% and 48.57% respectively.The treatment effectiveness of primary and secondary system amyloidosis was 32.72% and 74.19% respectively.The treatment effectiveness between different age is different signaficantly.The treatment effectiveness to single system,two systems,three systems,four systems are 75%,45%,29.41% and 5.88% respectively.Conclusion：Melphalan and hormone has the better clinical treatment result.The treatment to secondary amyloidosis is better than that of primary amyloidosis.Kidney is more sensitive to drugs.The treatment results changed with age and organs.And the best treatment time should be no longer than two weeks.
出处
《中国伤残医学》
2010年第2期16-19,共4页
Chinese Journal of Trauma and Disability Medicine
关键词
淀粉样变
药物治疗
临床疗效
美法仑
激素
Drug treatment
Amyloidosis
Clinical treatment effectiveness
Melphalan
Hormone
