摘要
目的探讨新发晚期血吸虫病(晚血)发生的危险因素。方法在洞庭湖2个血吸虫病流行县,采用1:2配对病例-对照研究。选择2006-2007年新发现的腹水型和巨脾型晚血病人60例作为病例组;以配对条件选择120例慢性血吸虫病人作为对照组。设计包含晚血危险因素的问卷,采用面对面的调查方式收集信息。使用SPSS12.0软件进行晚血病人发生的单因素及条件logistic回归的危险因素分析。结果乙肝病史(OR=10.729)、接触疫水方式(OR=3.919)、年均接触疫水天数(OR=5.457)和近10年化疗次数(OR=1.578)4个因素为晚血发生的危险因素;血吸虫病查出次数为晚血发生的保护因素;未发现晚血与年人均收入、文化程度、晚血家族史、血吸虫病检查次数和血清学检查阳性次数5个因素的关联性。结论长期接触疫水、反复感染、未能及时检查诊断和治疗是晚血发生的关键因素,合并乙肝病毒感染可加速晚血的形成。
Objective To explore the risk factors of newly emerging advanced schistosomiasis patients in endemic areas.Methods The study areas were selected in two counties of Dongting Lake regions and a 1：2 match case-control study was designed.Sixty schistosomiasis patients,who newly evolved into advanced schistosomiasis from 2006 to 2007,were selected into the case group,and 120 cases with chronic schistosomiasis into the control group.Questionnaires including potential risk factors of advanced schistosomiasis were designed and the information was collected based on face to face interviews.SPSS 12.0 was used to analyze the simple factors and multi ones （logistic regression） attributable to the development of advanced schistosomiasis.Results The history of hepatitis B （OR=10.729）,models of water contact （OR=3.919）,yearly exposure days to the infested water （OR=5.457） and times of chemotherapy in the nearly 10 years（OR=1.578）were the risk factors of development of advanced schistosomiasis.The times of examinations with positive schistosome eggs were protective factors.No association was found between yearly income,education degree,times of checking for schistosomiasis,times of examination with sera positive results and the emergence of advanced schistosomiasis.Conclusion The high frequency of exposure to the infested water,repeated infections,incomplete diagnosis and treatment are the risk factors of advanced schistosomiasis.The concurrent infection with hepatitis B is associated with the acceleration of development of advanced schistosomiasis.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2010年第2期145-149,共5页
Chinese Journal of Schistosomiasis Control
基金
湖南省卫生厅科研项目(B2006-197)
湖南省血吸虫病专家咨询委员会项目(2007-03)
