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合欢皮总皂苷对大鼠循环系统的影响 被引量:5

Effect caused by total Saponin of Cortex Albiziae on the circulation system of Rat
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摘要 目的观察合欢皮总皂苷低剂量组(5.25mg·kg-1)和高剂量组(26.25mg·kg-1)对大鼠血液循环系统及血液常规的影响。方法SD雄性大鼠,实验分为低剂量组(5.25mg·kg-1)、高剂量组(26.25mg·kg-1)及生理盐水(NS)对照组,生物信号记录系统记录给药后1h的血压、心电图(ECG)、脉搏及血常规的变化。动脉插管测定血压针式电极测定Ⅱ导联心电图,尾动脉记录脉搏波,细胞计数法测定血液常规。结果(1)血压:与正常对照组相比,低剂量组无显著变化,高剂量组明显升高。(2)脉搏:与正常对照组相比,低剂量组搏动频率、幅值和上升斜率均无显著差异;高剂量均增加。(3)心电图:与正常对照组相比,低剂量组无显著变化,高剂量组P-R间期和Q-T间期延长,P波、QR波S和T波幅值升高。(4)血液常规:低剂量对血常规无显著影响,高剂量使白细胞计数、血小板计数和血红蛋白含量明显下降。结论高剂量合欢皮总皂苷对大鼠血液及循环系统有一定的毒性作用。 OBJECTIVE To observe the effect caused by the low dose(5.25mg·kg-1)and the high dose(26.25mg·kg-1)of the Silktree Albizia on the blood and the circulation system of rats.METHODS The rats were divide into three groups,including low dose group(5.25mg·kg-1),high dose group(26.25mg·kg-1)and the cotrol group(NS)respectively.after administration 1h,the change of blood presure(BP)by arterial cannulation,electrocardiacgram(ECG)by needle node,pulse wave by caudal artery were recorded by the biologic signal system,and calculate the blood cells and the hemoglobin by counting method.RESULTS(1)Blood pressure:Compared with the control group,no difference was found in the low-dose group,and the blood pressure in the high dose group showed a significent increased.(2)Pulse:Compared with the control group,wave frequency,width value and ascensus slope rate in low dose group have no difference,while these index in high dose group were increased.(3)ECG:Compared with the control group,low-dose group found no obvious change in the index,while in the high dose group,the duration of P-R,QRS and Q-T was prolonged,and the amplitude of P wave and T wave showed increased.(4)Bood index:Compared with the control group,no significent difference was found in the low dose group,but in the high dose group,the number of the white blood cells(WBC),red blood cells(RBC),and the hemoglobin content were decreased.CONCLUSION The high dose of total saponin of the Silktree Albizia have certain toxicity to the rat's blood and the circulation system.
出处 《海峡药学》 2010年第2期28-30,共3页 Strait Pharmaceutical Journal
基金 江苏省中医药管理局资助项目(HE0817KY) 无锡市科技局资助项目
关键词 合欢皮 总皂苷 循环系统 血液常规 Cortex Albiziae total saponin circulation system blood cells
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  • 1钱玉昆.实用免疫学新技术[M].北京:北京医科大学中国协和医科大学联合出版社,1997.11-50.
  • 2王秀梅 贾炳权.吞噬细胞的吞噬和杀菌功能测定方法的改进[J].中华微生物学和免疫学杂志,1982,2(6):350-350.
  • 3郭峰.红细胞免疫学新探,第1版[M].南京:南京大学出版社,1993.95.
  • 4邹坤 赵玉英 等.从合欢皮中分得3具有细胞毒性的三萜皂甙[J].北京医科大学学报,1997,29(4):291-291.
  • 5田维毅 马春玲 等.合欢皮醇提取物的免疫活性研究[J].贵阳中医学院学报,1999,21:364-365.
  • 6邹坤 赵玉英 等.从合欢皮中分得3个具有细胞毒性的三萜皂甙[J].北京医科大学学报,1997,29(4):291-291.
  • 7田维毅 马春玲 等.合欢皮醇提物的免疫活性研究[J].贵阳中医学院学报,1999,21:364-365.
  • 8邹坤,赵玉英,郑俊华,张如意.从合欢皮中分得3个具有细胞毒活性的三萜皂甙[J]北京医科大学学报,1997(04).
  • 9邹坤,陈四平,赵玉英,张如意.合欢属植物茎皮的化学成分与药理活性[J].国外医药(植物药分册),1997,12(5):200-206. 被引量:27
  • 10郭峰.红细胞免疫及其调节功能测定方法[J].免疫学杂志,1990,6(1):60-66. 被引量:537

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