摘要
目的研究信号转导与转录活化因子(STAT3)和增值核抗原(PCNA)在胃癌中的表达情况及其在胃癌发生发展中的作用。方法采用免疫组化二步法检测40例胃癌组织和40例正常组织中STAT3与PCNA的表达。结果胃癌组织中STAT3的阳性表达率为65.0%,明显高于正常组织(27.5%)。PCNA的阳性表达率为57.6%,明显高于正常组织(25.0%)。STAT3的表达与临床分期、淋巴结是否转移和分化程度相关(P<0.05),与患者年龄、性别无关(P>0.05),并且与PCNA的表达呈正相关。结论STAT3的异常活化可促进细胞的过度增值,PCNA值可反映癌细胞的增值状态。二者联合检测可作为预测胃癌恶性程度和预后的重要方法,可能对胃癌的辅助诊断具有一定的意义。
Objective To study the expression of STAT3 and PCNA in Gastric cancer and to study the rela- tionship with the genesis and development of gastric cancer. Methods Immunohistochemistry method was used to examine the expression of PCNA and STAT3 in 40 gastric cancer and 40 gastric mucoma. Results The positive expression of STAT3 in gastric cancer（65.0% ） was significantly higher than that in gastric mucoma（27.5）. The positive expression of PCNA in gastric cancer（57.6% ） was significantly higher than that in gastric mucoma（25.0% ）. The expression of STAT3 in gastric cancer was significantly associated with the surgical stage,lymphatic invasion and differentiation（P 〈 0.05 ）. The expression of STAT3 was positively correlated with the expression of PCNA gene. Conclusion The expression of STAT3 is abnormal in gastric cancer, STAT3 may accelerate proliferation of gastric cancer. PCNA is reflect the proliferation of cancer cell. It has value to combined STAT3 and PCNA in diagnose and therapy of gastric cancer.
出处
《青海医学院学报》
CAS
2010年第1期24-28,共5页
Journal of Qinghai Medical College
