摘要
目的 探讨黄连素对2型糖尿病患者血清TNF-α及IL-6、胰岛素抵抗的影响及其可能机制.方法 将60例2型糖尿病患者随机分为对照组、罗格列酮组和黄连素组,并测定各组患者治疗前后的体重、空腹血糖（FBG）、空腹胰岛素和血清TNF-α、IL-6、C反应蛋白（CRP）、糖化血红蛋白（HbA1C）等指标;同时计算稳态模型评估胰岛素抵抗指数（HOMA-IR）和胰岛素敏感指数（ISI）.结果 黄连素组和罗格列酮组患者治疗后的FBG、HbA1C、血清TNF-α、IL-6、CRP及HOMA-IR均较自身治疗前和对照组明显降低（均P〈0.05或0.01）,ISI水平则均较自身治疗前和对照组显著增高（均P〈0.01）;而对照组治疗前、后上述指标间的差异均无统计学意义（均P〉0.05）.结论 黄连素具有降低2型糖尿病患者血糖、改善胰岛素抵抗的作用,其机制可能与降低患者血清TNF-α、IL-6等炎症因子有关.
Objective To investigate the effects of berberine on serum TNF-a and IL-6 levels, and insulin resistance of type 2 diabetic patients. Methods Sixty patients with type 2 diabetes were randomly divided into control group, rosiglitazon group and berberine group. The body weight, fasting plasma blood glucose （FBG）, fasting insulin, CRP, serum tumor necrosis factor-a （TNF-a） and interleukin-6 （IL-6） levels were evaluated before and after the treatment. The homeostasis model assessment for insulin resistance （HOMA-IR） and the insulin sensitive index （ISI） were calculated. Results Compared with results before treatment, the FBG, HbA1C, TNF-a, IL-6, CRP and H^MA-IR in berberine group and rosiglitazon group were decreased after treatment （P〈0.05）, the those in control group were not changed. Conclusion Berberine can decrease plasma glucose and HOMA-IR, which might be related to decrease of inflammatory factors such as TNF- a and IL-6.
出处
《浙江医学》
CAS
2010年第2期207-209,共3页
Zhejiang Medical Journal
