摘要
生命早期的营养状况逐渐被认识到能够改变成年期的发育和代谢状况,流行病学的证据和动物模型研究发现低出生体质量是成年期代谢综合征和心血管疾病的高危因素,胰岛素抵抗是其共同的病理生理基础,肾素-血管紧张素系统与胰岛素信号系统交互作用促进胰岛素抵抗的发生发展。
The nutritional status in early life have been gradually recognized that it can change the status of development and metabolism of adults.Epidemiological evidence and animal model study have found that low birth weight is the risk factors of adult metabolic syndrome and cardiovascular disease.Insulin resistance is a common pathophysiological basis.Renin-angiotensin system and insulin signaling systems interact to promote the development of insulin resistance.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2010年第8期603-606,共4页
Journal of Applied Clinical Pediatrics
关键词
低出生体质量
心血管疾病
胰岛素抵抗
机制
low birth weight
cardiovascular disease
insulin resistance
mechanism
