摘要
目的研究小陷胸汤加味方对兔心肌缺血再灌注心肌髓过氧化物酶(MPO)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)的影响。方法将32只健康新西兰大耳白兔随机分为4组:假手术组、模型组、小陷胸汤加味方低剂量组、小陷胸汤加味方高剂量组,每组8只。观察小陷胸汤加味方对MPO活性及TNF-α、CRP含量的干预。结果小陷胸汤加味方可降低兔心肌缺血再灌注MPO的活性及TNF-α、CRP的含量,与缺血再灌注组比较差异有统计学意义。结论小陷胸汤加味方对心肌缺血再灌注损伤具有保护作用。
Objective： To study the effects of additional Xiaoxianxiong Decoction on MPO, TNF-α and CRP in rabbits with myocardial ischemia reperfusion injury（MIRI） . Methods： 32 health rabbits were randomly into sham operation group, MIRI group, low dosage of additional Xiaoxianxiong Decoction group, high dosage of additional Xiaoxianxiong Decoction. The levels of MPO, TNF-α and CRP were investigated. Results： Additional Xiaoxianxiong Decoction could decrease the level of MPO, TNF-α and CRP. The levels of MPO, TNF-α and CRP were different obviously with additional Xiaoxianxiong Decoction group and MIRI group. Conclusion： Additional Xiaoxianxiong Decoction can protect the heart myocardial ischemia reperfusion injury.
出处
《中国中医急症》
2010年第4期633-635,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
河北省中医药管理局资助课题(No.2008043)
关键词
心肌缺血再灌注损伤
小陷胸汤加味方
髓过氧化物酶
肿瘤坏死因子-Α
C反应蛋白
Myocardial ischemia/reperfusion injury
Additional Xiaoxianxiong Decoction taste
myeloperoxidase
Tumor necrosis factor - α
C - reactive protein
