摘要
高迁移率族蛋白B1（high mobility group box 1 HMGB1）是高迁移率族蛋白家族成员之一。细胞外HMGBI和细胞表面受体——晚期糖基化终产物受体（receptor for advanced glycation endproduct，RAGE）、Toll样受体2（toll like receptor 2，TLR2）和Toll样受体4（toll like receptor 4，qLR4）结合，与其他促炎介质协同作用，促进炎症级联反应。脑缺血后，过度表达的HMGBl参与了炎症反应、神经元凋亡等病理生理学过程。
High mobility group box 1 （HMGB1） protein is one of the family members of high mobility group protein. Extracelltular HMGB1 binds with cell-surface receptors such as the receptor for advanced glycation endproduct （RAGE）, toll-like receptor 2（TLR2）, and toll- like receptor 4 （TLR4）. It synergies with other proinflammatory mediators and promotes the inflammatory cascade response. After cerebral ischemia, the overexpressed HMGB1 has involved in the pathophysiological processes, such as infammatory response and neuronal apoptosis.
出处
《国际脑血管病杂志》
北大核心
2010年第3期228-230,共3页
International Journal of Cerebrovascular Diseases
