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BCR-ABL酪氨酸激酶抑制剂的研究进展 被引量:6

Progress in the research of BCR-ABL tyrosine kinase inhibitors
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摘要 BCR-ABL融合基因表达出的酪氨酸激酶能引起细胞增殖、黏附和生存性质的改变,导致多种肿瘤的产生。抑制BCR-ABL酪氨酸激酶可有效抑制肿瘤生长。本文介绍了第一、二代以及新近开发的BCR-ABL酪氨酸激酶抑制剂。 The tyrosine kinases expressed by BCR-ABL fusion gene can cause cell proliferation,adhesion and survival natural change,several kinds of tumors can be caused by it.Inhibiting BCR-ABL tyrosine kinases can impede the growing progress of tumors.This paper introduces the first,second and some new BCR-ABL tyrosine kinases inhibitors.
作者 王伟 邹志红
出处 《东南大学学报(医学版)》 CAS 2010年第2期232-236,共5页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金资助项目(30770233)
关键词 BCR-ABL 酪氨酸激酶 抑制剂 慢性粒细胞白血病 综述 BCR-ABL tyrosine kinases inhibitors chronic myelogenous leukemia review
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参考文献33

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二级参考文献9

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