摘要
背景:牙髓干细胞、骨髓基质干细胞和牙周膜干细胞属于口腔中的成体干细胞,具有成体干细胞的两大特征:较强的自我更新能力和分化潜能。通过对口腔中多种干细胞的深入研究,有助于人类更加深入地揭示牙齿硬组织形成过程与诱导机制,进而指导临床相关治疗与预防。目的:总结各类口腔成体干细胞的特点及在临床中的应用前景。方法:由第一作者检索1999-01/2009-12 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及中国知网数据库(http://www.cnki.net)。英文检索词为"stemcell,dentistry",中文检索词为"干细胞,口腔医学"。检索文献量总计80篇,选择干细胞在口腔医学领域中的基础研究及临床应用,排除陈旧及重复实验文章,最终纳入19篇符合标准的文献。结果与结论:随着研究的深入,口腔特有的成体干细胞将会逐渐被发现,从而建立完整的干细胞库,为口腔各组织的组织工程研究提供可能的细胞来源。
BACKGROUND：The dental pulp stem cells,marrow mesenchymal stem cells and periodontal ligament stem cells belong to the adult stem cells from oral cavity,which own two features of the adult stem cells：the ability of renewing themselves strongly and the potential of splitting.Through the continuous study of many kinds of stem cells from oral cavity,it is very helpful for human to show the process of making the firm organizations of tooth and the inducing mechanism,in order to direct the related clinical work and the prevention work.OBJECTIVE：To summarize features and application perspective of various adult stem cells from oral cavity in the clinic.METHODS：The first author retrieved PubMed database（http：//www.ncbi.nlm.nih.gov/PubMed） and China National Knowledge Infrastructure（http：//www.cnki.net） for relevant literatures published from January 1999 to December 2009.The key words were ＂stem cell,dentistry＂.A total of 80 literatures were screened,and studies on basic research and clinical application of stem cells in stomatology medical field were included.Old and duplicated studies were excluded and finally 19 literatures were included.RESULTS AND CONCLUSION：With development of study,adult stem cells in oral cavity will be gradually found to establish integrated stem cell database,which can provide cell source for tissue engineering study in the oral cavity.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第14期2635-2637,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
省部高校共建专项基金[2005]1162~~
