摘要
对溶媒萃取工艺生产青霉素钠盐的碱化抽提工序进行改进,采用连续式生产代替传统的间歇式生产。根据萃取原理,采用正交试验设计,对实验数据进行优化处理,确定了适宜的工艺条件:碳酸钠质量分数6%,震荡时间5min,分相界面积12.1cm2。在该适宜条件下,进行了工业小试,得到的一次萃取收率均在96%以上,二次萃取收率均在99.9%以上。
To improve the alkali-extraction process in benzypenicillin sodium salt production,a continuous-process technology was adopted instead of the conventional intermittent production.Based on extraction principles,optimum process conditions were obtained by using orthogonal experimental design,which were found as 6% sodium carbonate solution,5min for vibration shock and 12.1cm2 sub-phase boundary area.An industrial test run was carried out under these conditions,the first extraction yield was entirely higher than 96% and the second extraction yield was higher than 99.9%.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2010年第5期963-967,共5页
Chemical Industry and Engineering Progress
关键词
青霉素钠
优化
萃取
正交试验
benzylpenicillin sodium
optimum
extraction
orthogonal experimental
